Apolipoprotein A-I in bile inhibits cholesterol crystallization and modifies transcellular lipid transfer through cultured human gall-bladder epithelial cells

Background: Apolipoprotein A‐I (Apo A‐I), conventionally purified by several steps including organic solvent‐delipidation from plasma, inhibits cholesterol crystallization in bile. To observe a significant effect in vitro, however, supraphysiological concentrations above 100 μg/mL are required. For...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 1999-05, Vol.14 (5), p.446-456
Hauptverfasser:	Secknus, Roger, Darby, Gwendolyn, Chernosky, Ann, Juvonen, Tatu, Moore, Edward, Holzbach, R Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	apolipoprotein A-I Apolipoprotein A-I - isolation & purification Apolipoprotein A-I - metabolism Apolipoprotein A-I - pharmacology Apolipoprotein A-I - physiology Bile - chemistry Binding, Competitive Biological and medical sciences Biological Transport Cells, Cultured cholesterol Cholesterol - metabolism Crystallization Epithelial Cells - drug effects Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology gall-bladder epithelium Gallbladder - drug effects Gallbladder - metabolism gallstones Humans Lipid Metabolism Liver. Bile. Biliary tracts Time Factors Vertebrates: digestive system
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