Functional T Cell Reconstitution and Human Immunodeficiency Virus—1—Specific Cell-Mediated Immunity during Highly Active Antiretroviral Therapy
Lymphoproliferative responses (LPRs) to recall antigens (Ags) and human immunodeficiency virus type 1 (HIV-1) Gag and frequencies of circulating HIV-1—specific cytotoxic T lymphocyte precursors (CTLps) were measured in 12 patients undergoing highly active antiretroviral therapy (HAART) after long-st...
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| Veröffentlicht in: | The Journal of infectious diseases 1999-07, Vol.180 (1), p.76-86 |
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| creator | Pontesilli, Oscar Kerkhof-Garde, Susana Notermans, Daan W. Foudraine, Norbert A. Roos, Marijke T. L. Klein, Michèl R. Danner, Sven A. Lange, Joep M. A. Miedema, Frank |
| description | Lymphoproliferative responses (LPRs) to recall antigens (Ags) and human immunodeficiency virus type 1 (HIV-1) Gag and frequencies of circulating HIV-1—specific cytotoxic T lymphocyte precursors (CTLps) were measured in 12 patients undergoing highly active antiretroviral therapy (HAART) after long-standing HIV-1 infection. LPRs to at least 1 recall Ag became detectable or increased in all patients during HAART. No significant LPRs to Gag-p24 were observed, whereas 4 of 8 patients tested presented with Gag-p17—specific LPRs. HIV-1—specific CTLp frequencies became measurable or increased early during therapy in 6 of 10 patients tested and were maintained or decreased thereafter. Increasing HIV-1—specific CTLp frequencies were seen only in association with partial HAART failure in 1 patient. In conclusion, restoration of CD4+ T lymphocyte responsiveness to recall Ags is achieved during HAART. The data provide evidence for limited HIV-1—specific CD4+ memory T cells during advanced HIV-1 infection and suggest that both CD4+ and CD8+ HIV-1—specific T cells are poorly stimulated when viral load is suppressed. |
| doi_str_mv | 10.1086/314837 |
| format | Article |
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Increasing HIV-1—specific CTLp frequencies were seen only in association with partial HAART failure in 1 patient. In conclusion, restoration of CD4+ T lymphocyte responsiveness to recall Ags is achieved during HAART. The data provide evidence for limited HIV-1—specific CD4+ memory T cells during advanced HIV-1 infection and suggest that both CD4+ and CD8+ HIV-1—specific T cells are poorly stimulated when viral load is suppressed.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314837</identifier><identifier>PMID: 10353864</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Antibiotics. Antiinfectious agents. 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L.</creatorcontrib><creatorcontrib>Klein, Michèl R.</creatorcontrib><creatorcontrib>Danner, Sven A.</creatorcontrib><creatorcontrib>Lange, Joep M. A.</creatorcontrib><creatorcontrib>Miedema, Frank</creatorcontrib><title>Functional T Cell Reconstitution and Human Immunodeficiency Virus—1—Specific Cell-Mediated Immunity during Highly Active Antiretroviral Therapy</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Lymphoproliferative responses (LPRs) to recall antigens (Ags) and human immunodeficiency virus type 1 (HIV-1) Gag and frequencies of circulating HIV-1—specific cytotoxic T lymphocyte precursors (CTLps) were measured in 12 patients undergoing highly active antiretroviral therapy (HAART) after long-standing HIV-1 infection. LPRs to at least 1 recall Ag became detectable or increased in all patients during HAART. No significant LPRs to Gag-p24 were observed, whereas 4 of 8 patients tested presented with Gag-p17—specific LPRs. HIV-1—specific CTLp frequencies became measurable or increased early during therapy in 6 of 10 patients tested and were maintained or decreased thereafter. Increasing HIV-1—specific CTLp frequencies were seen only in association with partial HAART failure in 1 patient. In conclusion, restoration of CD4+ T lymphocyte responsiveness to recall Ags is achieved during HAART. The data provide evidence for limited HIV-1—specific CD4+ memory T cells during advanced HIV-1 infection and suggest that both CD4+ and CD8+ HIV-1—specific T cells are poorly stimulated when viral load is suppressed.</description><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. 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L.</au><au>Klein, Michèl R.</au><au>Danner, Sven A.</au><au>Lange, Joep M. A.</au><au>Miedema, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional T Cell Reconstitution and Human Immunodeficiency Virus—1—Specific Cell-Mediated Immunity during Highly Active Antiretroviral Therapy</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>180</volume><issue>1</issue><spage>76</spage><epage>86</epage><pages>76-86</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Lymphoproliferative responses (LPRs) to recall antigens (Ags) and human immunodeficiency virus type 1 (HIV-1) Gag and frequencies of circulating HIV-1—specific cytotoxic T lymphocyte precursors (CTLps) were measured in 12 patients undergoing highly active antiretroviral therapy (HAART) after long-standing HIV-1 infection. LPRs to at least 1 recall Ag became detectable or increased in all patients during HAART. No significant LPRs to Gag-p24 were observed, whereas 4 of 8 patients tested presented with Gag-p17—specific LPRs. HIV-1—specific CTLp frequencies became measurable or increased early during therapy in 6 of 10 patients tested and were maintained or decreased thereafter. Increasing HIV-1—specific CTLp frequencies were seen only in association with partial HAART failure in 1 patient. In conclusion, restoration of CD4+ T lymphocyte responsiveness to recall Ags is achieved during HAART. The data provide evidence for limited HIV-1—specific CD4+ memory T cells during advanced HIV-1 infection and suggest that both CD4+ and CD8+ HIV-1—specific T cells are poorly stimulated when viral load is suppressed.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10353864</pmid><doi>10.1086/314837</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1999-07, Vol.180 (1), p.76-86 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adult AIDS AIDS/HIV Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Gene Products, gag - immunology Highly active antiretroviral therapy HIV 1 HIV Infections - drug therapy HIV Infections - immunology HIV Reverse Transcriptase - immunology HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Humans Immunity, Cellular Infections Infectious diseases Longitudinal Studies Lymphocytes Major Articles Male Medical sciences Memory recall Middle Aged Pharmacology. Drug treatments RNA T lymphocytes T-Lymphocytes, Cytotoxic - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral load Viruses |
| title | Functional T Cell Reconstitution and Human Immunodeficiency Virus—1—Specific Cell-Mediated Immunity during Highly Active Antiretroviral Therapy |
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