Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles

Injectable biodegradable and biocompatible copolymers of lactic and glycolic acid (PLGA) are an important advanced delivery system for week-to-month controlled release of hydrophobic drugs (e.g., from biopharmaceutical classification system class IV), which often display poor oral bioavailability. T...

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Veröffentlicht in:	International journal of pharmaceutics 2008-12, Vol.364 (2), p.298-327
Hauptverfasser:	Wischke, Christian, Schwendeman, Steven P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutical classification system Chemistry, Pharmaceutical - methods Controlled release Delayed-Action Preparations Drug Carriers - chemistry Drug Delivery Systems Hydrophobic and Hydrophilic Interactions Hydrophobic drug Lactic Acid - chemistry Microencapsulation Microparticle Microspheres Pharmaceutical Preparations - administration & dosage PLGA Polyesters Polyglycolic Acid - chemistry Polymers - chemistry Solvents - chemistry
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