Blood transfusion-induced anaphylaxis and coronary artery spasm during general anesthesia

Anaphylactic reactions to blood transfusion can lead to life-threatening cardiovascular disruptions. We describe a case in which anaphylaxis due to blood transfusion during general anesthesia was the probable cause of coronary artery spasm. Thirty minutes after the transfusion of concentrated red bl...

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Veröffentlicht in:Journal of anesthesia 2008, Vol.22 (4), p.457-459
Hauptverfasser: Osugi, Toshihiro, Ueki, Ryusuke, Shimode, Noriko, Tatara, Tsuneo, Tashiro, Chikara
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container_end_page 459
container_issue 4
container_start_page 457
container_title Journal of anesthesia
container_volume 22
creator Osugi, Toshihiro
Ueki, Ryusuke
Shimode, Noriko
Tatara, Tsuneo
Tashiro, Chikara
description Anaphylactic reactions to blood transfusion can lead to life-threatening cardiovascular disruptions. We describe a case in which anaphylaxis due to blood transfusion during general anesthesia was the probable cause of coronary artery spasm. Thirty minutes after the transfusion of concentrated red blood cells, the patient’s blood pressure had dropped to 70/40 mmHg and peak airway pressure had increased to 35 cmH 2 O. The ST segment of the ECG was simultaneously elevated, and the left upper arm became extensively flushed. The tryptase concentration in the patient’s plasma collected 3 h postoperatively was 13.9 μg·l −1 (normal range, 2.1–9.0 μg·l −1 ). This case report emphasizes that anaphylactic reactions to blood transfusion can potentially lead to coronary artery spasm.
doi_str_mv 10.1007/s00540-008-0658-7
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subjects Aged
Anaphylaxis - etiology
Anesthesia, General
Anesthesiology
Clinical Report
Coronary Vasospasm - etiology
Creatine Kinase - metabolism
Critical Care Medicine
Emergency Medicine
Erythrocyte Transfusion - adverse effects
Humans
Intensive
Male
Medicine
Medicine & Public Health
Pain Medicine
Transfusion Reaction
Tryptases - blood
title Blood transfusion-induced anaphylaxis and coronary artery spasm during general anesthesia
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