Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience
Background. We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck. Methods. Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (...
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| Veröffentlicht in: | Head & neck 2008-12, Vol.30 (12), p.1559-1565 |
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| creator | Shnayder, Yelizaveta Weed, Donald T. Arnold, David J. Gomez-Fernandez, Carmen Bared, Anthony Goodwin, W. Jarrard Civantos, Francisco J. |
| description | Background.
We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
Methods.
Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes.
Results.
Median follow‐up was 24 months (range, 5–84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow‐up of 24 months.
Conclusion.
Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early‐stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated. © 2008 Wiley Periodicals, Inc. Head Neck, 2008 |
| doi_str_mv | 10.1002/hed.20899 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69794005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69794005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4579-26893c8a46fcf852b76d3867a73ce2229c3729ec2ebd92d8ab40c4235ea6ec9e3</originalsourceid><addsrcrecordid>eNp10E1P2zAYB3ALbQIGHPYFJl-GtEPAsR073g0BoxOUadMAaRfrqfNk9Zo4xU43-u2X0tIbF9uyfs-L_oS8z9lJzhg_nWJ1wllpzA7Zz5nRGRNSv1m9pcgE03KPvEvpD2NMKMl3yV5eaqVzLfZJNYYAv7HF0NOupv0UaUA3oz7QMcYZNtRhMxwQnQ9dCy9oilBRCNWz_kzvgv-LMfl-uQJjD62n-DTH6DE4PCRva2gSHm3uA3L35fLn-Si7-Xb19fzsJnOy0CbjqjTClSBV7eqy4BOtKlEqDVo45JwbJzQ36DhOKsOrEiaSOclFgaDQGRQH5Hjddx67xwWm3rY-rfaHgN0iWWW0kYwVA_y0hi52KUWs7Tz6FuLS5syuIrVDpPY50sF-2DRdTNrhdys3GQ7g4wZActDUEYLzaeuGLoVgJh_c6dr98w0uX59oR5cXL6OzdYVPPT5tKyDOrNJCF_bh9sp-5w8_-K_Rtb0X_wGDn5va</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69794005</pqid></control><display><type>article</type><title>Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Shnayder, Yelizaveta ; Weed, Donald T. ; Arnold, David J. ; Gomez-Fernandez, Carmen ; Bared, Anthony ; Goodwin, W. Jarrard ; Civantos, Francisco J.</creator><creatorcontrib>Shnayder, Yelizaveta ; Weed, Donald T. ; Arnold, David J. ; Gomez-Fernandez, Carmen ; Bared, Anthony ; Goodwin, W. Jarrard ; Civantos, Francisco J.</creatorcontrib><description>Background.
We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
Methods.
Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes.
Results.
Median follow‐up was 24 months (range, 5–84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow‐up of 24 months.
Conclusion.
Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early‐stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated. © 2008 Wiley Periodicals, Inc. Head Neck, 2008</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.20899</identifier><identifier>PMID: 18767173</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Merkel Cell - pathology ; Carcinoma, Merkel Cell - radiotherapy ; Carcinoma, Merkel Cell - surgery ; Dermatology ; Feasibility Studies ; Florida ; Follow-Up Studies ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - radiotherapy ; Head and Neck Neoplasms - surgery ; Hospitals, University ; Humans ; immunohistochemistry ; Medical Records ; Medical sciences ; Merkel cell carcinoma ; Middle Aged ; neck dissection ; Neck Dissection - methods ; Otorhinolaryngology. Stomatology ; Postoperative Period ; Radiotherapy, Adjuvant ; Retrospective Studies ; Sentinel Lymph Node Biopsy ; skin carcinoma ; Skin Neoplasms - pathology ; Skin Neoplasms - radiotherapy ; Skin Neoplasms - surgery ; Survival Analysis ; Treatment Outcome ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Head & neck, 2008-12, Vol.30 (12), p.1559-1565</ispartof><rights>Copyright © 2008 Wiley Periodicals, Inc.</rights><rights>2008 INIST-CNRS</rights><rights>(c) 2008 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4579-26893c8a46fcf852b76d3867a73ce2229c3729ec2ebd92d8ab40c4235ea6ec9e3</citedby><cites>FETCH-LOGICAL-c4579-26893c8a46fcf852b76d3867a73ce2229c3729ec2ebd92d8ab40c4235ea6ec9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.20899$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.20899$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20853091$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18767173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shnayder, Yelizaveta</creatorcontrib><creatorcontrib>Weed, Donald T.</creatorcontrib><creatorcontrib>Arnold, David J.</creatorcontrib><creatorcontrib>Gomez-Fernandez, Carmen</creatorcontrib><creatorcontrib>Bared, Anthony</creatorcontrib><creatorcontrib>Goodwin, W. Jarrard</creatorcontrib><creatorcontrib>Civantos, Francisco J.</creatorcontrib><title>Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
Methods.
Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes.
Results.
Median follow‐up was 24 months (range, 5–84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow‐up of 24 months.
Conclusion.
Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early‐stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated. © 2008 Wiley Periodicals, Inc. Head Neck, 2008</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Carcinoma, Merkel Cell - radiotherapy</subject><subject>Carcinoma, Merkel Cell - surgery</subject><subject>Dermatology</subject><subject>Feasibility Studies</subject><subject>Florida</subject><subject>Follow-Up Studies</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Merkel cell carcinoma</subject><subject>Middle Aged</subject><subject>neck dissection</subject><subject>Neck Dissection - methods</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Postoperative Period</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>skin carcinoma</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - radiotherapy</subject><subject>Skin Neoplasms - surgery</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1P2zAYB3ALbQIGHPYFJl-GtEPAsR073g0BoxOUadMAaRfrqfNk9Zo4xU43-u2X0tIbF9uyfs-L_oS8z9lJzhg_nWJ1wllpzA7Zz5nRGRNSv1m9pcgE03KPvEvpD2NMKMl3yV5eaqVzLfZJNYYAv7HF0NOupv0UaUA3oz7QMcYZNtRhMxwQnQ9dCy9oilBRCNWz_kzvgv-LMfl-uQJjD62n-DTH6DE4PCRva2gSHm3uA3L35fLn-Si7-Xb19fzsJnOy0CbjqjTClSBV7eqy4BOtKlEqDVo45JwbJzQ36DhOKsOrEiaSOclFgaDQGRQH5Hjddx67xwWm3rY-rfaHgN0iWWW0kYwVA_y0hi52KUWs7Tz6FuLS5syuIrVDpPY50sF-2DRdTNrhdys3GQ7g4wZActDUEYLzaeuGLoVgJh_c6dr98w0uX59oR5cXL6OzdYVPPT5tKyDOrNJCF_bh9sp-5w8_-K_Rtb0X_wGDn5va</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Shnayder, Yelizaveta</creator><creator>Weed, Donald T.</creator><creator>Arnold, David J.</creator><creator>Gomez-Fernandez, Carmen</creator><creator>Bared, Anthony</creator><creator>Goodwin, W. Jarrard</creator><creator>Civantos, Francisco J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience</title><author>Shnayder, Yelizaveta ; Weed, Donald T. ; Arnold, David J. ; Gomez-Fernandez, Carmen ; Bared, Anthony ; Goodwin, W. Jarrard ; Civantos, Francisco J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4579-26893c8a46fcf852b76d3867a73ce2229c3729ec2ebd92d8ab40c4235ea6ec9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Carcinoma, Merkel Cell - radiotherapy</topic><topic>Carcinoma, Merkel Cell - surgery</topic><topic>Dermatology</topic><topic>Feasibility Studies</topic><topic>Florida</topic><topic>Follow-Up Studies</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Merkel cell carcinoma</topic><topic>Middle Aged</topic><topic>neck dissection</topic><topic>Neck Dissection - methods</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Postoperative Period</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>skin carcinoma</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - radiotherapy</topic><topic>Skin Neoplasms - surgery</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shnayder, Yelizaveta</creatorcontrib><creatorcontrib>Weed, Donald T.</creatorcontrib><creatorcontrib>Arnold, David J.</creatorcontrib><creatorcontrib>Gomez-Fernandez, Carmen</creatorcontrib><creatorcontrib>Bared, Anthony</creatorcontrib><creatorcontrib>Goodwin, W. Jarrard</creatorcontrib><creatorcontrib>Civantos, Francisco J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shnayder, Yelizaveta</au><au>Weed, Donald T.</au><au>Arnold, David J.</au><au>Gomez-Fernandez, Carmen</au><au>Bared, Anthony</au><au>Goodwin, W. Jarrard</au><au>Civantos, Francisco J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2008-12</date><risdate>2008</risdate><volume>30</volume><issue>12</issue><spage>1559</spage><epage>1565</epage><pages>1559-1565</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
Methods.
Records of 15 patients with MCC of the head and neck area were evaluated for the type of surgical treatment, including wide local excision, sentinel lymph node (SLN) biopsy, neck dissection, postoperative radiation therapy, and clinical outcomes.
Results.
Median follow‐up was 24 months (range, 5–84 months). Ten patients were treated with wide local excision plus SLN, with or without neck dissection. Five patients were treated with wide local excision only or wide local excision plus neck dissection. One patient died of distant metastases (7%), and 14 patients remain alive (93%), over a mean follow‐up of 24 months.
Conclusion.
Wide excision and SLN biopsy for primary MCC with N0 neck is feasible for early‐stage, previously untreated lesions. SLN biopsy was helpful in determining the nodal levels to be dissected or irradiated. © 2008 Wiley Periodicals, Inc. Head Neck, 2008</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18767173</pmid><doi>10.1002/hed.20899</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - radiotherapy Carcinoma, Merkel Cell - surgery Dermatology Feasibility Studies Florida Follow-Up Studies Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - surgery Hospitals, University Humans immunohistochemistry Medical Records Medical sciences Merkel cell carcinoma Middle Aged neck dissection Neck Dissection - methods Otorhinolaryngology. Stomatology Postoperative Period Radiotherapy, Adjuvant Retrospective Studies Sentinel Lymph Node Biopsy skin carcinoma Skin Neoplasms - pathology Skin Neoplasms - radiotherapy Skin Neoplasms - surgery Survival Analysis Treatment Outcome Tumors of the skin and soft tissue. Premalignant lesions |
| title | Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience |
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