Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR

BRCA1 is a breast cancer susceptibility gene that is down-regulated in a significant proportion of sporadic breast cancers. BRCA1 is posttranscriptionally regulated by RNA-binding proteins, the identities of which are unknown. HuR is an RNA binding protein implicated in posttranscriptional regulatio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-11, Vol.68 (22), p.9469-9478
Hauptverfasser:	Saunus, Jodi M, French, Juliet D, Edwards, Stacey L, Beveridge, Dianne J, Hatchell, Esme C, Wagner, Sarah A, Stein, Sandra R, Davidson, Andrew, Simpson, Kaylene J, Francis, Glenn D, Leedman, Peter J, Brown, Melissa A
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - chemistry Antigens, Surface - analysis Antigens, Surface - chemistry Antigens, Surface - metabolism Binding Sites Breast Neoplasms - genetics Breast Neoplasms - pathology ELAV Proteins ELAV-Like Protein 1 Female Gene Expression Regulation Genes, BRCA1 Genetic Predisposition to Disease Humans Middle Aged RNA, Messenger - metabolism RNA-Binding Proteins - analysis RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism
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