Acute phase proteins in cattle: discrimination between acute and chronic inflammation
Acute phase proteins such as serum amyloid A, haptoglobin, and α1 -acid glycoprotein have been identified as markers of inflammation in cattle because they are produced by the liver in response to pro-inflammatory cytokines. This study was designed to assess whether they could be used to discriminat...
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| Veröffentlicht in: | Veterinary record 1999-04, Vol.144 (16), p.437-441 |
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| creator | Horadagoda, N. U. Knox, K.M. G. Gibbs, H. A. Reid, S. W. J. Horadagoda, A. Edwards, S. E. R. Eckersall, P. D. |
| description | Acute phase proteins such as serum amyloid A, haptoglobin, and α1 -acid glycoprotein have been identified as markers of inflammation in cattle because they are produced by the liver in response to pro-inflammatory cytokines. This study was designed to assess whether they could be used to discriminate between acute and chronic inflammation. Their concentrations were measured in serum samples from 81 cattle in which inflammation was classified by thorough clinical examination, supported by postmortem findings, as being acute in severity in 31 and chronic in 50. The classical haematological markers of inflammation were also determined in blood from the animals. Serum amyloid A had a maximum (100 per cent) clinical sensitivity in discriminating between the acute and chronic cases, and haptoglobin had the highest clinical specificity of 76 per cent; counts of neutrophils and band neutrophils had sensitivities of 71 per cent and 42 per cent and specificities of 30 per cent and 72 per cent, respectively. It was concluded that serum amyloid A and haptoglobin may be used to discriminate between acute and chronic inflammatory conditions. |
| doi_str_mv | 10.1136/vr.144.16.437 |
| format | Article |
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Serum amyloid A had a maximum (100 per cent) clinical sensitivity in discriminating between the acute and chronic cases, and haptoglobin had the highest clinical specificity of 76 per cent; counts of neutrophils and band neutrophils had sensitivities of 71 per cent and 42 per cent and specificities of 30 per cent and 72 per cent, respectively. It was concluded that serum amyloid A and haptoglobin may be used to discriminate between acute and chronic inflammatory conditions.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.144.16.437</identifier><identifier>PMID: 10343375</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>Acute Disease ; Acute-Phase Proteins - analysis ; Animals ; Cattle ; Cattle Diseases - diagnosis ; Cattle Diseases - immunology ; Chronic Disease ; Diagnosis, Differential ; Female ; Inflammation - diagnosis ; Inflammation - veterinary ; Male ; Sensitivity and Specificity</subject><ispartof>Veterinary record, 1999-04, Vol.144 (16), p.437-441</ispartof><rights>British Veterinary Association. All rights reserved.</rights><rights>1999 British Veterinary Association</rights><rights>Copyright: 1999 British Veterinary Association. 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| ispartof | Veterinary record, 1999-04, Vol.144 (16), p.437-441 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease Acute-Phase Proteins - analysis Animals Cattle Cattle Diseases - diagnosis Cattle Diseases - immunology Chronic Disease Diagnosis, Differential Female Inflammation - diagnosis Inflammation - veterinary Male Sensitivity and Specificity |
| title | Acute phase proteins in cattle: discrimination between acute and chronic inflammation |
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