p53 in mitochondria enhances the accuracy of DNA synthesis

Mitochondrial localization of p53 was observed in stressed and unstressed cells. p53 is involved in DNA repair and apoptosis. It exerts physical and functional interactions with mitochondrial DNA and DNA polymerase γ (pol γ ). The functional cooperation of p53 and pol γ during DNA synthesis was exam...

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Veröffentlicht in:	Cell death and differentiation 2008-12, Vol.15 (12), p.1865-1874
Hauptverfasser:	Bakhanashvili, M, Grinberg, S, Bonda, E, Simon, A J, Moshitch-Moshkovitz, S, Rahav, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Cooperation DNA - biosynthesis DNA polymerase DNA repair DNA Repair - radiation effects Exodeoxyribonucleases - metabolism Genomes Guanosine Triphosphate - metabolism Humans Life Sciences Mitochondria Mitochondria - metabolism Mitochondria - radiation effects Mitochondrial DNA Models, Biological Mutation original-paper Polymerization Proteins Radiation, Ionizing Stem Cells Subcellular Fractions - radiation effects Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - metabolism Tumors
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