human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

The human brain endothelial capillary cell line hCMEC/D3 has been developed recently as a model for the human blood-brain barrier. In this study a further characterization of this model was performed with special emphasis on permeability properties and active drug transport. Para- or transcellular p...

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Veröffentlicht in:	Journal of neurochemistry 2008-12, Vol.107 (5), p.1358-1368
Hauptverfasser:	Poller, Birk, Gutmann, Heike, Krähenbühl, Stephan, Weksler, Babette, Romero, Ignacio, Couraud, Pierre-Olivier, Tuffin, Gerald, Drewe, Jürgen, Huwyler, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCB1 ABCG2 Analysis of Variance ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biochemistry Biochemistry and metabolism Biological and medical sciences Biological Transport blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain - blood supply Brain - cytology Cell culture Cell Line Central nervous system Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Endothelial Cells - cytology Endothelial Cells - metabolism Flow Cytometry - methods Fundamental and applied biological sciences. Psychology Humans Midazolam - metabolism Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neurology p-glycoprotein permeability Pharmacology Receptors, Transferrin - genetics Receptors, Transferrin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sucrose - metabolism transendothelial transport Vertebrates: nervous system and sense organs
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