Effects of a Long-Term High-Fat Diet and Switching from a High-Fat to Low-Fat, Standard Diet on Hepatic Fat Accumulation in Sprague-Dawley Rats
To investigate the effects of a long-term high-fat diet and switching from high-fat to a low-fat diet on hepatic fat accumulation in Sprague-Dawley (SD) rats, 3-week-old male SD rats were fed a high-fat diet (HFD) containing 45% fat (kilocalories) for 43 weeks (HDHD group), an HFD for 23 weeks follo...
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| Veröffentlicht in: | Digestive diseases and sciences 2008-12, Vol.53 (12), p.3206-3212 |
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| creator | Omagari, Katsuhisa Kato, Shigeko Tsuneyama, Koichi Inohara, Chisato Kuroda, Yu Tsukuda, Hiroe Fukazawa, Eri Shiraishi, Keiko Mune, Masatoshi |
| description | To investigate the effects of a long-term high-fat diet and switching from high-fat to a low-fat diet on hepatic fat accumulation in Sprague-Dawley (SD) rats, 3-week-old male SD rats were fed a high-fat diet (HFD) containing 45% fat (kilocalories) for 43 weeks (HDHD group), an HFD for 23 weeks followed by a low-fat, standard diet (LFD) containing 10% fat for 20 weeks (HDLD group), and an LFD for 43 weeks (LDLD group). Histopathologically, steatosis and lobular inflammation was obvious in the HDLD and HDHD groups at 46 weeks of age, and ballooning hepatocytes and Mallory hyalines were seen in the HDHD group. Mild fibrosis was observed in 5 of 13 (38%) rats in the HDHD or HDLD groups. Our results demonstrate that a long-term high-fat diet can induce nonalcoholic steatohepatitis (NASH) in SD rats. Switching to a low-fat, standard diet prevented the progression of NASH, although steatosis was not improved. |
| doi_str_mv | 10.1007/s10620-008-0303-1 |
| format | Article |
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Histopathologically, steatosis and lobular inflammation was obvious in the HDLD and HDHD groups at 46 weeks of age, and ballooning hepatocytes and Mallory hyalines were seen in the HDHD group. Mild fibrosis was observed in 5 of 13 (38%) rats in the HDHD or HDLD groups. Our results demonstrate that a long-term high-fat diet can induce nonalcoholic steatohepatitis (NASH) in SD rats. Switching to a low-fat, standard diet prevented the progression of NASH, although steatosis was not improved.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-008-0303-1</identifier><identifier>PMID: 18465233</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adipose Tissue - metabolism ; Animals ; Biochemistry ; Biological and medical sciences ; Blood Pressure - drug effects ; Body Fat Distribution ; Body Weight - drug effects ; Diet, Fat-Restricted ; Dietary Fats - pharmacology ; Disease Models, Animal ; Disease Progression ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Hepatocytes - pathology ; Hepatology ; Hyalin - metabolism ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic diseases ; Obesity ; Oncology ; Original Paper ; Other diseases. 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Histopathologically, steatosis and lobular inflammation was obvious in the HDLD and HDHD groups at 46 weeks of age, and ballooning hepatocytes and Mallory hyalines were seen in the HDHD group. Mild fibrosis was observed in 5 of 13 (38%) rats in the HDHD or HDLD groups. Our results demonstrate that a long-term high-fat diet can induce nonalcoholic steatohepatitis (NASH) in SD rats. Switching to a low-fat, standard diet prevented the progression of NASH, although steatosis was not improved.</description><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Body Fat Distribution</subject><subject>Body Weight - drug effects</subject><subject>Diet, Fat-Restricted</subject><subject>Dietary Fats - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Hepatocytes - pathology</subject><subject>Hepatology</subject><subject>Hyalin - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Other diseases. 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Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Hepatocytes - pathology</topic><topic>Hepatology</topic><topic>Hyalin - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Other diseases. Semiology</topic><topic>Proteins - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Transplant Surgery</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omagari, Katsuhisa</creatorcontrib><creatorcontrib>Kato, Shigeko</creatorcontrib><creatorcontrib>Tsuneyama, Koichi</creatorcontrib><creatorcontrib>Inohara, Chisato</creatorcontrib><creatorcontrib>Kuroda, Yu</creatorcontrib><creatorcontrib>Tsukuda, Hiroe</creatorcontrib><creatorcontrib>Fukazawa, Eri</creatorcontrib><creatorcontrib>Shiraishi, Keiko</creatorcontrib><creatorcontrib>Mune, Masatoshi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omagari, Katsuhisa</au><au>Kato, Shigeko</au><au>Tsuneyama, Koichi</au><au>Inohara, Chisato</au><au>Kuroda, Yu</au><au>Tsukuda, Hiroe</au><au>Fukazawa, Eri</au><au>Shiraishi, Keiko</au><au>Mune, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Long-Term High-Fat Diet and Switching from a High-Fat to Low-Fat, Standard Diet on Hepatic Fat Accumulation in Sprague-Dawley Rats</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>53</volume><issue>12</issue><spage>3206</spage><epage>3212</epage><pages>3206-3212</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>To investigate the effects of a long-term high-fat diet and switching from high-fat to a low-fat diet on hepatic fat accumulation in Sprague-Dawley (SD) rats, 3-week-old male SD rats were fed a high-fat diet (HFD) containing 45% fat (kilocalories) for 43 weeks (HDHD group), an HFD for 23 weeks followed by a low-fat, standard diet (LFD) containing 10% fat for 20 weeks (HDLD group), and an LFD for 43 weeks (LDLD group). Histopathologically, steatosis and lobular inflammation was obvious in the HDLD and HDHD groups at 46 weeks of age, and ballooning hepatocytes and Mallory hyalines were seen in the HDHD group. Mild fibrosis was observed in 5 of 13 (38%) rats in the HDHD or HDLD groups. Our results demonstrate that a long-term high-fat diet can induce nonalcoholic steatohepatitis (NASH) in SD rats. Switching to a low-fat, standard diet prevented the progression of NASH, although steatosis was not improved.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>18465233</pmid><doi>10.1007/s10620-008-0303-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Adipose Tissue - metabolism Animals Biochemistry Biological and medical sciences Blood Pressure - drug effects Body Fat Distribution Body Weight - drug effects Diet, Fat-Restricted Dietary Fats - pharmacology Disease Models, Animal Disease Progression Fatty Liver - metabolism Fatty Liver - pathology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Hepatology Hyalin - metabolism Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Metabolic diseases Obesity Oncology Original Paper Other diseases. Semiology Proteins - metabolism Rats Rats, Sprague-Dawley Time Factors Transplant Surgery Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of a Long-Term High-Fat Diet and Switching from a High-Fat to Low-Fat, Standard Diet on Hepatic Fat Accumulation in Sprague-Dawley Rats |
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