One-Pot Tandem Decarboxylative Allylation−Heck Cyclization of Allyl Diphenylglycinate Imines: Rapid Access to Polyfunctionalized 1-Aminoindanes

1-Aminoindanes are generated from allyl diphenylglycinate imines employing a “one-pot” palladium-catalyzed decarboxylative allylation−Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products a...

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Veröffentlicht in:	Organic letters 2008-11, Vol.10 (22), p.5131-5134
Hauptverfasser:	Fields, Wendy H, Khan, Ali K, Sabat, Michal, Chruma, Jason J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Catalysis Cyclization Decarboxylation Glycine - chemistry Imines - chemistry Indans - chemistry Palladium - chemistry Time Factors
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description	1-Aminoindanes are generated from allyl diphenylglycinate imines employing a “one-pot” palladium-catalyzed decarboxylative allylation−Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules.
doi_str_mv	10.1021/ol801986m
format	Article
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subjects	Alkenes - chemistry Catalysis Cyclization Decarboxylation Glycine - chemistry Imines - chemistry Indans - chemistry Palladium - chemistry Time Factors
title	One-Pot Tandem Decarboxylative Allylation−Heck Cyclization of Allyl Diphenylglycinate Imines: Rapid Access to Polyfunctionalized 1-Aminoindanes
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