Effects of Tetracycline and Spectinomycin on the Tertiary Structure of Ribosomal RNA in the Escherichia coli 30 S Ribosomal Subunit

Structural analysis of the 16 S rRNA in the 30 S subunit and 70 S ribosome in the presence of ribosome-specific antibiotics was performed to determine whether they produced rRNA structural changes that might provide further insight to their action. An UV cross-linking procedure that determines the p...

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Veröffentlicht in:	The Journal of biological chemistry 1999-06, Vol.274 (23), p.16576-16581
Hauptverfasser:	Noah, J W, Dolan, M A, Babin, P, Wollenzien, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Base Sequence Electrophoresis, Polyacrylamide Gel Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - radiation effects Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Ribosomes - radiation effects Ribosomes - ultrastructure RNA, Bacterial - drug effects RNA, Bacterial - metabolism RNA, Bacterial - radiation effects RNA, Ribosomal, 16S - drug effects RNA, Ribosomal, 16S - radiation effects RNA, Ribosomal, 16S - ultrastructure Spectinomycin - pharmacology Tetracycline - pharmacology Ultraviolet Rays
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