Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas
Macrophages are key participants in angiogenesis. In this study on human brain tumors, we first investigated whether macrophage infiltration is associated with angiogenesis and malignant histological appearance. Immunostaining of macrophages and small vessels in resected glioma specimens indicated t...
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Veröffentlicht in: | Clinical cancer research 1999-05, Vol.5 (5), p.1107-1113 |
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Zusammenfassung: | Macrophages are key participants in angiogenesis. In this study on human brain tumors, we first investigated whether macrophage
infiltration is associated with angiogenesis and malignant histological appearance. Immunostaining of macrophages and small
vessels in resected glioma specimens indicated that numbers of infiltrating macrophages and small vessel density were higher
in glioblastomas than in astrocytomas or anaplastic astrocytomas. Macrophage infiltration was closely correlated with vascular
density in human gliomas. Heme oxygenase-1 (HO-1), which is the rate-limiting enzyme in heme catabolism, was also associated
with activated macrophages. Expression of mRNA encoding HO-1 was correlated with macrophage infiltration and vascular density
in human glioma samples. Infiltrating macrophages were positively stained with anti-HO-1 antibody by immunohistochemical analysis,
and in situ hybridization for HO-1 indicated that HO-1 was expressed in infiltrating macrophages in gliomas. HO-1 gene may be a useful marker for macrophage infiltration as well as neovascularization in human gliomas. |
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ISSN: | 1078-0432 1557-3265 |