Effect of lipid extracted from tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme activity, antioxidant activity, plasma and liver lipids, and blood glucose levels of mice
Lipids extracted from tsao-ko were separated into three fractions with silica gel column chromatography and fed to mice (3 mo old) for 90 d to clarify their inhibitory activity on digestive enzyme activity. The diets contained the following: control-no tsao-ko, 0.05% total lipid of tsao-ko (TL), 0.0...
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| creator | Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)) Shirai, N Suzuki, H Hosono, T Nakajima, Y Kajiwara, M Takatori, K |
| description | Lipids extracted from tsao-ko were separated into three fractions with silica gel column chromatography and fed to mice (3 mo old) for 90 d to clarify their inhibitory activity on digestive enzyme activity. The diets contained the following: control-no tsao-ko, 0.05% total lipid of tsao-ko (TL), 0.0109% chloroform fraction (CF), 0.0245% acetone fraction (AF), or 0.00365% methanol fraction (MeF). Although CF and AF slightly inhibited the activities of alpha-glucosidase, alpha-amylase, and lipase, intakes of these fractions had little influence on plasma and liver lipid concentrations when compared with the control diet. MeF did not inhibit alpha-glucosidase but had DPPH radical scavenging activity and the mice fed this fraction had the most marked reduction in plasma glucose and TBARS concentrations compared with the other diet groups. These results suggest that the fat-soluble polar components of tsao-ko contain an active component that might be associated with decreased plasma glucose and TBARS concentrations in mice. |
| doi_str_mv | 10.3177/jnsv.54.378 |
| format | Article |
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The diets contained the following: control-no tsao-ko, 0.05% total lipid of tsao-ko (TL), 0.0109% chloroform fraction (CF), 0.0245% acetone fraction (AF), or 0.00365% methanol fraction (MeF). Although CF and AF slightly inhibited the activities of alpha-glucosidase, alpha-amylase, and lipase, intakes of these fractions had little influence on plasma and liver lipid concentrations when compared with the control diet. MeF did not inhibit alpha-glucosidase but had DPPH radical scavenging activity and the mice fed this fraction had the most marked reduction in plasma glucose and TBARS concentrations compared with the other diet groups. These results suggest that the fat-soluble polar components of tsao-ko contain an active component that might be associated with decreased plasma glucose and TBARS concentrations in mice.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.54.378</identifier><identifier>PMID: 19001769</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>ALIMENTACION ; ALIMENTATION ; alpha-Amylases - metabolism ; alpha-Glucosidases - metabolism ; Amomum - chemistry ; Animals ; ANTIOXIDANTES ; ANTIOXIDANTS ; Antioxidants - metabolism ; ANTIOXYDANT ; Biological and medical sciences ; Blood Glucose - metabolism ; BLOOD PLASMA ; Body Composition - drug effects ; Digestive System - enzymology ; ENZIMAS ; ENZYME ; ENZYMES ; EXTRACTOS ; EXTRACTS ; EXTRAIT ; FEEDING ; Feeding. Feeding behavior ; FOIE ; Free Radical Scavengers - pharmacology ; Fundamental and applied biological sciences. Psychology ; GLUCOSA ; GLUCOSE ; HIGADO ; Hypolipidemic Agents - isolation & purification ; Hypolipidemic Agents - pharmacology ; inhibitory activity ; Lipase - metabolism ; Lipid Metabolism - drug effects ; Lipids - blood ; lipids, DPPH ; LIVER ; Male ; MICE ; Mice, Inbred Strains ; OXIDES ; OXIDOS ; OXYDE ; Plant Extracts - pharmacology ; Plant Oils - isolation & purification ; Plant Oils - pharmacology ; PLASMA SANGUIN ; PLASMA SANGUINEO ; RATON ; SOURIS ; Thiobarbituric Acid Reactive Substances ; tsao-ko ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; ZINGIBERACEAE ; ZINGIBERACEAS</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2008, Vol.54(5), pp.378-383</ispartof><rights>2008 by the Center for Academic Publications Japan</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-6f03fb25c2f1d08a8e81ff7a40e985623c89dcfeb762713eb9fbfef9a3a15eb23</citedby><cites>FETCH-LOGICAL-c605t-6f03fb25c2f1d08a8e81ff7a40e985623c89dcfeb762713eb9fbfef9a3a15eb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20889404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19001769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan))</creatorcontrib><creatorcontrib>Shirai, N</creatorcontrib><creatorcontrib>Suzuki, H</creatorcontrib><creatorcontrib>Hosono, T</creatorcontrib><creatorcontrib>Nakajima, Y</creatorcontrib><creatorcontrib>Kajiwara, M</creatorcontrib><creatorcontrib>Takatori, K</creatorcontrib><title>Effect of lipid extracted from tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme activity, antioxidant activity, plasma and liver lipids, and blood glucose levels of mice</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>Lipids extracted from tsao-ko were separated into three fractions with silica gel column chromatography and fed to mice (3 mo old) for 90 d to clarify their inhibitory activity on digestive enzyme activity. The diets contained the following: control-no tsao-ko, 0.05% total lipid of tsao-ko (TL), 0.0109% chloroform fraction (CF), 0.0245% acetone fraction (AF), or 0.00365% methanol fraction (MeF). Although CF and AF slightly inhibited the activities of alpha-glucosidase, alpha-amylase, and lipase, intakes of these fractions had little influence on plasma and liver lipid concentrations when compared with the control diet. MeF did not inhibit alpha-glucosidase but had DPPH radical scavenging activity and the mice fed this fraction had the most marked reduction in plasma glucose and TBARS concentrations compared with the other diet groups. These results suggest that the fat-soluble polar components of tsao-ko contain an active component that might be associated with decreased plasma glucose and TBARS concentrations in mice.</description><subject>ALIMENTACION</subject><subject>ALIMENTATION</subject><subject>alpha-Amylases - metabolism</subject><subject>alpha-Glucosidases - metabolism</subject><subject>Amomum - chemistry</subject><subject>Animals</subject><subject>ANTIOXIDANTES</subject><subject>ANTIOXIDANTS</subject><subject>Antioxidants - metabolism</subject><subject>ANTIOXYDANT</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>BLOOD PLASMA</subject><subject>Body Composition - drug effects</subject><subject>Digestive System - enzymology</subject><subject>ENZIMAS</subject><subject>ENZYME</subject><subject>ENZYMES</subject><subject>EXTRACTOS</subject><subject>EXTRACTS</subject><subject>EXTRAIT</subject><subject>FEEDING</subject><subject>Feeding. Feeding behavior</subject><subject>FOIE</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCOSA</subject><subject>GLUCOSE</subject><subject>HIGADO</subject><subject>Hypolipidemic Agents - isolation & purification</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>inhibitory activity</subject><subject>Lipase - metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>lipids, DPPH</subject><subject>LIVER</subject><subject>Male</subject><subject>MICE</subject><subject>Mice, Inbred Strains</subject><subject>OXIDES</subject><subject>OXIDOS</subject><subject>OXYDE</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Oils - isolation & purification</subject><subject>Plant Oils - pharmacology</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>RATON</subject><subject>SOURIS</subject><subject>Thiobarbituric Acid Reactive Substances</subject><subject>tsao-ko</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>ZINGIBERACEAE</subject><subject>ZINGIBERACEAS</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2P0zAQhiMEYsvCiTPIFxCITbHzZfvGqlq-VAkOcI4mzri4OHGx3WjLL-Pn4ZKqy8Ujzzx63xm9WfaU0WXJOH-7HcO0rKtlycW9bMGEYDnnVXE_W9CSsrwSlF5kj0LYUlpJUYmH2QWTlDLeyEX250ZrVJE4TazZmZ7gbfSgIvZEezeQGMDlPx15dT24YX_3X3mcXIgEI1njAMbja-JG0psNhmgmJDj-PgxIkpSZTDxcERijcbemT_W_7s5CGCAN--Q_oZ-3CFf_Op11ricbu1cuILE4oQ3HTQej8HH2QIMN-ORUL7Pv72--rT7m6y8fPq2u17lqaB3zRtNSd0WtCs16KkCgYFpzqChKUTdFqYTslcaONwVnJXZSdxq1hBJYjV1RXmYvZ92dd7_26bh2MEGhtTCi24e2kVw0nDUJfDODyrsQPOp2580A_tAy2h6Dao9BtXXVpqAS_fwku-8G7O_YUzIJeHECICiw2sOoTDhzBRVCVrRK3LuZ24YIGzwD4KNRFs-m9fwk7_NI_QDf4pgkns0SGlwLG59sPn8tKE2rUCFl-RfxtMB-</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan))</creator><creator>Shirai, N</creator><creator>Suzuki, H</creator><creator>Hosono, T</creator><creator>Nakajima, Y</creator><creator>Kajiwara, M</creator><creator>Takatori, K</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Effect of lipid extracted from tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme activity, antioxidant activity, plasma and liver lipids, and blood glucose levels of mice</title><author>Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)) ; Shirai, N ; Suzuki, H ; Hosono, T ; Nakajima, Y ; Kajiwara, M ; Takatori, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-6f03fb25c2f1d08a8e81ff7a40e985623c89dcfeb762713eb9fbfef9a3a15eb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ALIMENTACION</topic><topic>ALIMENTATION</topic><topic>alpha-Amylases - metabolism</topic><topic>alpha-Glucosidases - metabolism</topic><topic>Amomum - chemistry</topic><topic>Animals</topic><topic>ANTIOXIDANTES</topic><topic>ANTIOXIDANTS</topic><topic>Antioxidants - metabolism</topic><topic>ANTIOXYDANT</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>BLOOD PLASMA</topic><topic>Body Composition - drug effects</topic><topic>Digestive System - enzymology</topic><topic>ENZIMAS</topic><topic>ENZYME</topic><topic>ENZYMES</topic><topic>EXTRACTOS</topic><topic>EXTRACTS</topic><topic>EXTRAIT</topic><topic>FEEDING</topic><topic>Feeding. Feeding behavior</topic><topic>FOIE</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCOSA</topic><topic>GLUCOSE</topic><topic>HIGADO</topic><topic>Hypolipidemic Agents - isolation & purification</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>inhibitory activity</topic><topic>Lipase - metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids - blood</topic><topic>lipids, DPPH</topic><topic>LIVER</topic><topic>Male</topic><topic>MICE</topic><topic>Mice, Inbred Strains</topic><topic>OXIDES</topic><topic>OXIDOS</topic><topic>OXYDE</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Oils - isolation & purification</topic><topic>Plant Oils - pharmacology</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>RATON</topic><topic>SOURIS</topic><topic>Thiobarbituric Acid Reactive Substances</topic><topic>tsao-ko</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>ZINGIBERACEAE</topic><topic>ZINGIBERACEAS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan))</creatorcontrib><creatorcontrib>Shirai, N</creatorcontrib><creatorcontrib>Suzuki, H</creatorcontrib><creatorcontrib>Hosono, T</creatorcontrib><creatorcontrib>Nakajima, Y</creatorcontrib><creatorcontrib>Kajiwara, M</creatorcontrib><creatorcontrib>Takatori, K</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, L.(Tokyo Univ. of Agriculture and Technology, Fuchu (Japan))</au><au>Shirai, N</au><au>Suzuki, H</au><au>Hosono, T</au><au>Nakajima, Y</au><au>Kajiwara, M</au><au>Takatori, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of lipid extracted from tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme activity, antioxidant activity, plasma and liver lipids, and blood glucose levels of mice</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>54</volume><issue>5</issue><spage>378</spage><epage>383</epage><pages>378-383</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Lipids extracted from tsao-ko were separated into three fractions with silica gel column chromatography and fed to mice (3 mo old) for 90 d to clarify their inhibitory activity on digestive enzyme activity. The diets contained the following: control-no tsao-ko, 0.05% total lipid of tsao-ko (TL), 0.0109% chloroform fraction (CF), 0.0245% acetone fraction (AF), or 0.00365% methanol fraction (MeF). Although CF and AF slightly inhibited the activities of alpha-glucosidase, alpha-amylase, and lipase, intakes of these fractions had little influence on plasma and liver lipid concentrations when compared with the control diet. MeF did not inhibit alpha-glucosidase but had DPPH radical scavenging activity and the mice fed this fraction had the most marked reduction in plasma glucose and TBARS concentrations compared with the other diet groups. These results suggest that the fat-soluble polar components of tsao-ko contain an active component that might be associated with decreased plasma glucose and TBARS concentrations in mice.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>19001769</pmid><doi>10.3177/jnsv.54.378</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ALIMENTACION ALIMENTATION alpha-Amylases - metabolism alpha-Glucosidases - metabolism Amomum - chemistry Animals ANTIOXIDANTES ANTIOXIDANTS Antioxidants - metabolism ANTIOXYDANT Biological and medical sciences Blood Glucose - metabolism BLOOD PLASMA Body Composition - drug effects Digestive System - enzymology ENZIMAS ENZYME ENZYMES EXTRACTOS EXTRACTS EXTRAIT FEEDING Feeding. Feeding behavior FOIE Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology GLUCOSA GLUCOSE HIGADO Hypolipidemic Agents - isolation & purification Hypolipidemic Agents - pharmacology inhibitory activity Lipase - metabolism Lipid Metabolism - drug effects Lipids - blood lipids, DPPH LIVER Male MICE Mice, Inbred Strains OXIDES OXIDOS OXYDE Plant Extracts - pharmacology Plant Oils - isolation & purification Plant Oils - pharmacology PLASMA SANGUIN PLASMA SANGUINEO RATON SOURIS Thiobarbituric Acid Reactive Substances tsao-ko Vertebrates: anatomy and physiology, studies on body, several organs or systems ZINGIBERACEAE ZINGIBERACEAS |
| title | Effect of lipid extracted from tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme activity, antioxidant activity, plasma and liver lipids, and blood glucose levels of mice |
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