Iodine Balance, Iatrogenic Excess, and Thyroid Dysfunction in Premature Newborns
Iodine is a trace element that is essential for the synthesis of thyroid hormones. The thyroid hormones, thyroxine and 3,5,3′-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine...
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Veröffentlicht in: | Seminars in perinatology 2008-12, Vol.32 (6), p.407-412 |
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description | Iodine is a trace element that is essential for the synthesis of thyroid hormones. The thyroid hormones, thyroxine and 3,5,3′-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula preparations used to feed them. An inadequate iodine supply (deficiency and excess) might be especially dangerous in the case of premature babies. The minimum recommended dietary allowance is different depending on age groups. The iodine intake required is at least 15 μg/kg/d in full-term infants and 30 μg/kg/d in preterms. Premature infants are in a situation of iodine deficiency, precisely at a stage of psychomotor and neural development that is extremely sensitive to alterations of thyroid function. |
doi_str_mv | 10.1053/j.semperi.2008.09.006 |
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The thyroid hormones, thyroxine and 3,5,3′-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula preparations used to feed them. An inadequate iodine supply (deficiency and excess) might be especially dangerous in the case of premature babies. The minimum recommended dietary allowance is different depending on age groups. The iodine intake required is at least 15 μg/kg/d in full-term infants and 30 μg/kg/d in preterms. 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The thyroid hormones, thyroxine and 3,5,3′-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula preparations used to feed them. An inadequate iodine supply (deficiency and excess) might be especially dangerous in the case of premature babies. The minimum recommended dietary allowance is different depending on age groups. The iodine intake required is at least 15 μg/kg/d in full-term infants and 30 μg/kg/d in preterms. Premature infants are in a situation of iodine deficiency, precisely at a stage of psychomotor and neural development that is extremely sensitive to alterations of thyroid function.</description><subject>breast milk</subject><subject>Female</subject><subject>Humans</subject><subject>hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - metabolism</subject><subject>Infant Formula</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Infant, Premature - metabolism</subject><subject>Iodine - administration & dosage</subject><subject>Iodine - metabolism</subject><subject>iodine intake</subject><subject>Milk, Human</subject><subject>Neonatal and Perinatal Medicine</subject><subject>Pregnancy</subject><subject>thyroid hormone</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid Hormones - deficiency</subject><subject>Thyroid Hormones - metabolism</subject><issn>0146-0005</issn><issn>1558-075X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvhI4By4tSEsRP_yQVUSoGVKqhEkbhZjj0LXhJ7sRNgvz1e7UpIXLjMXN57o_k9Qp5SaCjw9sW2yTjtMPmGAagG-gZA3CMryrmqQfIv98kKaCdqAOBn5FHOW4C26yk8JGe0B5BCqhW5XUfnA1avzWiCxYtqbeYUv2Lwtrr-bTHni8oEV91926foXfVmnzdLsLOPofKhuk04mXlJWH3AX0NMIT8mDzZmzPjktM_J57fXd1fv65uP79ZXlze17aia68Fyp7q2s4rzlgEbhGE4yKEdnDOOgaBCcJAbx3sxDNJKI1UvGTOKoaDQtufk-TF3l-KPBfOsJ58tjuUNjEvWopdKcMmKkB-FNsWcE270LvnJpL2moA8o9VafUOoDSg29LiiL79npwDJM6P66TuyK4NVRgOXNnx6TztZjgeh8QjtrF_1_T7z8J8GOvpA343fcY97GJYXCUFOdmQb96dDnoU5QALSM9g-dNpwO</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Ares, Susana, MD, PhD</creator><creator>Quero, Jose, MD, PhD</creator><creator>de Escobar, Gabriella Morreale, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Iodine Balance, Iatrogenic Excess, and Thyroid Dysfunction in Premature Newborns</title><author>Ares, Susana, MD, PhD ; Quero, Jose, MD, PhD ; de Escobar, Gabriella Morreale, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-bc5d8434c8553202b6a2eb7b3bddad206166507fd596bb7c7a789722a82e61033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>breast milk</topic><topic>Female</topic><topic>Humans</topic><topic>hypothyroidism</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - metabolism</topic><topic>Infant Formula</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Infant, Premature - metabolism</topic><topic>Iodine - administration & dosage</topic><topic>Iodine - metabolism</topic><topic>iodine intake</topic><topic>Milk, Human</topic><topic>Neonatal and Perinatal Medicine</topic><topic>Pregnancy</topic><topic>thyroid hormone</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid Hormones - deficiency</topic><topic>Thyroid Hormones - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ares, Susana, MD, PhD</creatorcontrib><creatorcontrib>Quero, Jose, MD, PhD</creatorcontrib><creatorcontrib>de Escobar, Gabriella Morreale, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ares, Susana, MD, PhD</au><au>Quero, Jose, MD, PhD</au><au>de Escobar, Gabriella Morreale, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iodine Balance, Iatrogenic Excess, and Thyroid Dysfunction in Premature Newborns</atitle><jtitle>Seminars in perinatology</jtitle><addtitle>Semin Perinatol</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>32</volume><issue>6</issue><spage>407</spage><epage>412</epage><pages>407-412</pages><issn>0146-0005</issn><eissn>1558-075X</eissn><abstract>Iodine is a trace element that is essential for the synthesis of thyroid hormones. The thyroid hormones, thyroxine and 3,5,3′-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula preparations used to feed them. An inadequate iodine supply (deficiency and excess) might be especially dangerous in the case of premature babies. The minimum recommended dietary allowance is different depending on age groups. The iodine intake required is at least 15 μg/kg/d in full-term infants and 30 μg/kg/d in preterms. Premature infants are in a situation of iodine deficiency, precisely at a stage of psychomotor and neural development that is extremely sensitive to alterations of thyroid function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19007678</pmid><doi>10.1053/j.semperi.2008.09.006</doi><tpages>6</tpages></addata></record> |
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subjects | breast milk Female Humans hypothyroidism Hypothyroidism - blood Hypothyroidism - metabolism Infant Formula Infant, Newborn Infant, Premature - blood Infant, Premature - metabolism Iodine - administration & dosage Iodine - metabolism iodine intake Milk, Human Neonatal and Perinatal Medicine Pregnancy thyroid hormone Thyroid Hormones - blood Thyroid Hormones - deficiency Thyroid Hormones - metabolism |
title | Iodine Balance, Iatrogenic Excess, and Thyroid Dysfunction in Premature Newborns |
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