4-Arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients

Objective To investigate the proapoptotic capacities of four arylcoumarin analogues of combretastatins on leukemic cells from B-cell chronic lymphocytic leukemia (CLL), a malignancy characterized by apoptosis deficiency. Materials and Methods The effects of the four compounds on several nuclear, mem...

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Veröffentlicht in:	Experimental hematology 2008-12, Vol.36 (12), p.1625-1633
Hauptverfasser:	Billard, Christian, Menasria, Faouzia, Quiney, Claire, Faussat, Anne-Marie, Finet, Jean-Pierre, Combes, Sébastien, Kolb, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Aged Amino Acid Chloromethyl Ketones - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Bibenzyls - pharmacology Caspase 3 - metabolism Caspase Inhibitors Cyclin-Dependent Kinase Inhibitor p27 Cysteine Proteinase Inhibitors - pharmacology DNA Fragmentation - drug effects Drug Screening Assays, Antitumor Enzyme Activation - drug effects Female Hematology, Oncology and Palliative Medicine Humans Intracellular Signaling Peptides and Proteins - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Male Middle Aged Myeloid Cell Leukemia Sequence 1 Protein Proto-Oncogene Proteins c-bcl-2 - metabolism Tumor Cells, Cultured
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