Inhibition of cation channels and suicidal death of human erythrocytes by zidovudine

Abstract Zidovudine, a drug widely used in the treatment of AIDS, has been shown to influence cytosolic calcium activity in HIV-infected lymphocytes. Thus, zidovudine may modify the activity of Ca2+ -permeable ion channels. In erythrocytes, activation of Ca2+ -permeable cation channels stimulates er...

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Veröffentlicht in:	Toxicology (Amsterdam) 2008-11, Vol.253 (1), p.62-69
Hauptverfasser:	Kucherenko, Yuliya, Geiger, Corinna, Shumilina, Ekaterina, Föller, Michael, Lang, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aniline Compounds Annexin Annexin A5 - metabolism Azathioprine - pharmacology Biological and medical sciences Calcium Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Cell Death - drug effects Cell volume Cytosol - metabolism Emergency Eryptosis Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - ultrastructure Gluconates - metabolism Human immunodeficiency virus Humans Medical sciences Patch-Clamp Techniques Phosphatidylserine Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sodium Chloride - metabolism Suicide Toxicology Xanthenes Zidovudine - pharmacology
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