Protective effect of vitamin C on oxidative stress: a randomized controlled trial
Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma. Using the ROS assay system, a method recently established by one of the authors, we aimed to evalu...
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2008-05, Vol.78 (3), p.121-128 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Sasazuki, Shizuka Hayashi, Tomonori Nakachi, Kei Sasaki, Satoshi Tsubono, Yoshitaka Okubo, Shunji Hayashi, Masato Tsugane, Shoichiro |
| description | Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma.
Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis. |
| doi_str_mv | 10.1024/0300-9831.78.3.121 |
| format | Article |
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Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.</description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831.78.3.121</identifier><identifier>PMID: 19003734</identifier><identifier>CODEN: IJVNAP</identifier><language>eng</language><publisher>Bern: Huber</publisher><subject>Adult ; Aged ; Analysis of Variance ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; ascorbic acid ; Ascorbic Acid - blood ; Ascorbic Acid - therapeutic use ; Biological and medical sciences ; Chronic Disease ; chronic diseases ; Dietary Supplements ; Dose-Response Relationship, Drug ; Female ; gastritis ; Gastritis, Atrophic - blood ; Gastritis, Atrophic - microbiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - blood ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Humans ; Japan ; Japanese people ; Male ; Medical sciences ; men ; Middle Aged ; middle-aged adults ; Other diseases. Semiology ; oxidative stress ; Oxidative Stress - drug effects ; protective effect ; randomized clinical trials ; reactive oxygen species ; Reactive Oxygen Species - blood ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; vitamin supplements ; women</subject><ispartof>International journal for vitamin and nutrition research, 2008-05, Vol.78 (3), p.121-128</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-910baf6177fa3f8ca0c881fdbb7c591981598e8d43c4c22660837d2b3fc040c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20894508$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19003734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasazuki, Shizuka</creatorcontrib><creatorcontrib>Hayashi, Tomonori</creatorcontrib><creatorcontrib>Nakachi, Kei</creatorcontrib><creatorcontrib>Sasaki, Satoshi</creatorcontrib><creatorcontrib>Tsubono, Yoshitaka</creatorcontrib><creatorcontrib>Okubo, Shunji</creatorcontrib><creatorcontrib>Hayashi, Masato</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><title>Protective effect of vitamin C on oxidative stress: a randomized controlled trial</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma.
Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - therapeutic use</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>chronic diseases</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>gastritis</subject><subject>Gastritis, Atrophic - blood</subject><subject>Gastritis, Atrophic - microbiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Japan</subject><subject>Japanese people</subject><subject>Male</subject><subject>Medical sciences</subject><subject>men</subject><subject>Middle Aged</subject><subject>middle-aged adults</subject><subject>Other diseases. Semiology</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>protective effect</subject><subject>randomized clinical trials</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - blood</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>vitamin supplements</subject><subject>women</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFu1DAQhi1URLeFF-BAfaG3LDO2Ezu9VStakCoBgj1bjmMjoyRu7eyq8PQ47Go5zX_4_hnNR8hbhDUCEx-AA1St4riWas3XyPAFWWHTiIophmdkdQLOyUXOvwC4RCVekXNsl8zFinz7muLs7Bz2jjrvS6LR032YzRgmuqFxovE59OYfkOfkcr6hhiYz9XEMf1xPbZzmFIehxDkFM7wmL70ZsntznJdke_fxx-ZT9fDl_vPm9qGyvK7nqkXojG9QSm-4V9aAVQp933XS1i22CutWOdULboVlrGlAcdmzjnsLAqzgl-T6sPcxxaedy7MeQ7ZuGMzk4i7rppWqBqkKyA6gTTHn5Lx-TGE06bdG0ItIvXjSiyctlea6iCyld8ftu250_f_K0VwB3h8Bk60ZfDFiQz5xDFQraliuXx04b6I2P1Nhtt8ZIIfyINbA-V9RTYPX</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Sasazuki, Shizuka</creator><creator>Hayashi, Tomonori</creator><creator>Nakachi, Kei</creator><creator>Sasaki, Satoshi</creator><creator>Tsubono, Yoshitaka</creator><creator>Okubo, Shunji</creator><creator>Hayashi, Masato</creator><creator>Tsugane, Shoichiro</creator><general>Huber</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Protective effect of vitamin C on oxidative stress: a randomized controlled trial</title><author>Sasazuki, Shizuka ; Hayashi, Tomonori ; Nakachi, Kei ; Sasaki, Satoshi ; Tsubono, Yoshitaka ; Okubo, Shunji ; Hayashi, Masato ; Tsugane, Shoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-910baf6177fa3f8ca0c881fdbb7c591981598e8d43c4c22660837d2b3fc040c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - therapeutic use</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>chronic diseases</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>gastritis</topic><topic>Gastritis, Atrophic - blood</topic><topic>Gastritis, Atrophic - microbiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Japan</topic><topic>Japanese people</topic><topic>Male</topic><topic>Medical sciences</topic><topic>men</topic><topic>Middle Aged</topic><topic>middle-aged adults</topic><topic>Other diseases. Semiology</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>protective effect</topic><topic>randomized clinical trials</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - blood</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>vitamin supplements</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasazuki, Shizuka</creatorcontrib><creatorcontrib>Hayashi, Tomonori</creatorcontrib><creatorcontrib>Nakachi, Kei</creatorcontrib><creatorcontrib>Sasaki, Satoshi</creatorcontrib><creatorcontrib>Tsubono, Yoshitaka</creatorcontrib><creatorcontrib>Okubo, Shunji</creatorcontrib><creatorcontrib>Hayashi, Masato</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasazuki, Shizuka</au><au>Hayashi, Tomonori</au><au>Nakachi, Kei</au><au>Sasaki, Satoshi</au><au>Tsubono, Yoshitaka</au><au>Okubo, Shunji</au><au>Hayashi, Masato</au><au>Tsugane, Shoichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of vitamin C on oxidative stress: a randomized controlled trial</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>78</volume><issue>3</issue><spage>121</spage><epage>128</epage><pages>121-128</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><coden>IJVNAP</coden><abstract>Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma.
Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.</abstract><cop>Bern</cop><pub>Huber</pub><pmid>19003734</pmid><doi>10.1024/0300-9831.78.3.121</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Analysis of Variance Antioxidants - metabolism Antioxidants - therapeutic use ascorbic acid Ascorbic Acid - blood Ascorbic Acid - therapeutic use Biological and medical sciences Chronic Disease chronic diseases Dietary Supplements Dose-Response Relationship, Drug Female gastritis Gastritis, Atrophic - blood Gastritis, Atrophic - microbiology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - blood Helicobacter Infections - microbiology Helicobacter pylori Humans Japan Japanese people Male Medical sciences men Middle Aged middle-aged adults Other diseases. Semiology oxidative stress Oxidative Stress - drug effects protective effect randomized clinical trials reactive oxygen species Reactive Oxygen Species - blood Stomach. Duodenum. Small intestine. Colon. Rectum. Anus vitamin supplements women |
| title | Protective effect of vitamin C on oxidative stress: a randomized controlled trial |
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