Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis
A 40‐year‐old man developed squamous cell carcinoma on a perianal lesion of linear porokeratosis after renal transplantation. The tumor metastasized to the left inguinal lymph node 25 months after the primary tumor was excised. p53 overexpression was observed in the tumor cells, but not in the porok...
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| Veröffentlicht in: | Journal of dermatology 1999-04, Vol.26 (4), p.244-247 |
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| container_end_page | 247 |
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| container_issue | 4 |
| container_start_page | 244 |
| container_title | Journal of dermatology |
| container_volume | 26 |
| creator | Anzai, Saburo Takeo, Naoko Yamaguchi, Tomiko Sato, Toshihiro Takasaki, Syuji Terashi, Hiroto Takayasu, Susumu Takahashi, Shinichi |
| description | A 40‐year‐old man developed squamous cell carcinoma on a perianal lesion of linear porokeratosis after renal transplantation. The tumor metastasized to the left inguinal lymph node 25 months after the primary tumor was excised. p53 overexpression was observed in the tumor cells, but not in the porokeratotic lesion. Interestingly, continuous subcutaneous infusion of peplomycin for the lymph node metastasis significantly improved the warty lesions of porokeratosis. In this patient, immunosuppressive agents might have accelerated the development of carcinoma on a skin area with malignant potential. |
| doi_str_mv | 10.1111/j.1346-8138.1999.tb03465.x |
| format | Article |
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The tumor metastasized to the left inguinal lymph node 25 months after the primary tumor was excised. p53 overexpression was observed in the tumor cells, but not in the porokeratotic lesion. Interestingly, continuous subcutaneous infusion of peplomycin for the lymph node metastasis significantly improved the warty lesions of porokeratosis. 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In this patient, immunosuppressive agents might have accelerated the development of carcinoma on a skin area with malignant potential.</description><subject>Adult</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Leg</subject><subject>Male</subject><subject>porokeratosis</subject><subject>Porokeratosis - complications</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency - complications</subject><subject>Renal Insufficiency - therapy</subject><subject>renal transplantation</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - pathology</subject><subject>squamous cell carcinoma</subject><subject>Transplantation Immunology - physiology</subject><subject>Treatment Outcome</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAQQC0EomX5BRRx4JbgJc7CCRTKpkps5Ww5yVi4ZGntVG3_HodUiCtzmdH4zVjzEDonOCAuLucBYWHkJ4QlAUnTNOhy7Bo82Oyh8e_TPhpjlnCfhjgeoSNr5xjTlBN8iEbE8SyMyRi9vi9Xsm5X1sugqrxMmkI3bS093XjSe4NGVt7MyMYuKtl0rlHohQZXrXX36U11A9J4L61pv8DIrrXanqADJSsLp7t8jD7uJrPswZ8-3z9mN1O_YCTiforLOFHAiFI4jVXOKJQ8jkgOlFIe8lKBImUeKc4JJHHBIFUhThhThNCSRuwYXQx7F6ZdrsB2ota2cEfIBtw9IkrjhIUhdeDVABamtdaAEguja2m2gmDRCxVz0VsTvTXRCxU7oWLjhs92v6zyGso_o4NBB1wPwFpXsP3HavF0O_kp2TcpvYZc</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>Anzai, Saburo</creator><creator>Takeo, Naoko</creator><creator>Yamaguchi, Tomiko</creator><creator>Sato, Toshihiro</creator><creator>Takasaki, Syuji</creator><creator>Terashi, Hiroto</creator><creator>Takayasu, Susumu</creator><creator>Takahashi, Shinichi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis</title><author>Anzai, Saburo ; Takeo, Naoko ; Yamaguchi, Tomiko ; Sato, Toshihiro ; Takasaki, Syuji ; Terashi, Hiroto ; Takayasu, Susumu ; Takahashi, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3165-90d78fe31ff097fb32ed5761be222545dfef1db6f551e87c3e9f40833f112d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - immunology</topic><topic>Leg</topic><topic>Male</topic><topic>porokeratosis</topic><topic>Porokeratosis - complications</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency - complications</topic><topic>Renal Insufficiency - therapy</topic><topic>renal transplantation</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - pathology</topic><topic>squamous cell carcinoma</topic><topic>Transplantation Immunology - physiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anzai, Saburo</creatorcontrib><creatorcontrib>Takeo, Naoko</creatorcontrib><creatorcontrib>Yamaguchi, Tomiko</creatorcontrib><creatorcontrib>Sato, Toshihiro</creatorcontrib><creatorcontrib>Takasaki, Syuji</creatorcontrib><creatorcontrib>Terashi, Hiroto</creatorcontrib><creatorcontrib>Takayasu, Susumu</creatorcontrib><creatorcontrib>Takahashi, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anzai, Saburo</au><au>Takeo, Naoko</au><au>Yamaguchi, Tomiko</au><au>Sato, Toshihiro</au><au>Takasaki, Syuji</au><au>Terashi, Hiroto</au><au>Takayasu, Susumu</au><au>Takahashi, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>1999-04</date><risdate>1999</risdate><volume>26</volume><issue>4</issue><spage>244</spage><epage>247</epage><pages>244-247</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>A 40‐year‐old man developed squamous cell carcinoma on a perianal lesion of linear porokeratosis after renal transplantation. 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| fulltext | fulltext |
| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 1999-04, Vol.26 (4), p.244-247 |
| issn | 0385-2407 1346-8138 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Adult Antibiotics, Antineoplastic - therapeutic use Biopsy, Needle Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - pathology Follow-Up Studies Humans Kidney Transplantation - adverse effects Kidney Transplantation - immunology Leg Male porokeratosis Porokeratosis - complications Renal Dialysis Renal Insufficiency - complications Renal Insufficiency - therapy renal transplantation Skin Neoplasms - drug therapy Skin Neoplasms - etiology Skin Neoplasms - pathology squamous cell carcinoma Transplantation Immunology - physiology Treatment Outcome |
| title | Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis |
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