Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer

A possible epigenetic regulation of the two isoenzymes of fructose 1,6-bisphosphatase (FBPase) was studied in liver, muscle, mamma, breast cancer and in different cancer cell lines. Results obtained after bisulfite sequencing revealed a different CpG methylation of both promoters in liver, muscle an...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-12, Vol.377 (2), p.720-724
Hauptverfasser:	Bigl, Marina, Jandrig, Burkhard, Horn, Lars-Christian, Eschrich, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Azacitidine - pharmacology Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Cell line Cell Line, Tumor DNA methylation DNA Methylation - drug effects Female Fructose 1,6-bisphosphatase Fructose-Bisphosphatase - genetics Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Silencing Gluconeogenesis Humans Hydroxamic Acids - pharmacology Middle Aged Neoplasms - enzymology Neoplasms - genetics Promoter Promoter Regions, Genetic Tissue-specific expression
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