Human β‐defensin 3 binds to hemagglutinin B (rHagB), a non‐fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro‐inflammatory cytokine response

Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro‐inflammatory cytokine responses. Here, we asked whether human β‐defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro‐inflammatory cytokine responses to recom...

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Veröffentlicht in:	Immunology and cell biology 2008-11, Vol.86 (8), p.643-649
Hauptverfasser:	Pingel, Lindsey C, Kohlgraf, Karl G, Hansen, Christopher J, Eastman, Christopher G, Dietrich, Deborah E, Burnell, Kindra K, Srikantha, Rupasree N, Xiao, Xiangjun, Bélanger, Myriam, Progulske‐Fox, Ann, Cavanaugh, Joseph E, Guthmiller, Janet M, Johnson, Georgia K, Joly, Sophie, Kurago, Zoya B, Dawson, Deborah V, Brogden, Kim A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Adhesins, Bacterial - metabolism beta-Defensins - immunology beta-Defensins - metabolism Cytokines - immunology Cytokines - metabolism defensin Dendritic Cells - immunology Dendritic Cells - metabolism Extracellular Signal-Regulated MAP Kinases HBD3 Humans Immunity, Innate innate immunity Lectins - immunology Lectins - metabolism MAP Kinase Signaling System Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - immunology pro‐inflammatory cytokine suppression Recombinant Proteins - metabolism Surface Plasmon Resonance
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