LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential

A key step in the skin sensitization process is the formation of a covalent adduct between skin sensitizers and endogenous proteins and/or peptides in the skin. Based on this mechanistic understanding, there is a renewed interest in in vitro assays to determine the reactivity of chemicals toward pep...

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Veröffentlicht in:	Toxicological sciences 2008-12, Vol.106 (2), p.464-478
Hauptverfasser:	Natsch, Andreas, Gfeller, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	adduct formation alternative test Animal Testing Alternatives Chromatography, High Pressure Liquid - methods Humans LC-MS Local Lymph Node Assay peptide reactivity Peptides - chemistry Peptides - drug effects Skin - drug effects skin sensitization Spectrometry, Mass, Electrospray Ionization - methods Spectrophotometry, Ultraviolet
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