Adxanthromycin: a new inhibitor of ICAM-1/LFA-1 mediated cell adhesion from Streptomyces sp. NA-148
Intercellular adhesion molecule-1 (ICAM-1: CD54) and lymphocyte function-associated antigen-1 (LFA-1: CD11a/CD18) are cell surface adhesion molecules that interact with one another to promote a number of cellular interactions. A search for inhibitors of the ICAM-1/LFA-1 system from microbial metabol...
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| Veröffentlicht in: | Journal of antibiotics 1999, Vol.52 (2), p.198-200 |
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| container_title | Journal of antibiotics |
| container_volume | 52 |
| creator | Koiwa, T Nakano, T Takahashi, S Koshino, H Yamazaki, M Takashi, T Nakagawa, A |
| description | Intercellular adhesion molecule-1 (ICAM-1: CD54) and lymphocyte function-associated antigen-1 (LFA-1: CD11a/CD18) are cell surface adhesion molecules that interact with one another to promote a number of cellular interactions. A search for inhibitors of the ICAM-1/LFA-1 system from microbial metabolites was carried out using two methodologies: a homotypic cell aggregation assay and a cell adhesion assay. During the screening program, we found a new inhibitor, designated adxanthromycin, in the cultured broth of strain Streptomyces sp. NA-148. In this communication we describe the screening, isolation, structure, and biological properties of adxanthromycin. |
| doi_str_mv | 10.7164/antibiotics.52.198 |
| format | Article |
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| subjects | Anthracenes Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology B-Lymphocytes - drug effects Cell Adhesion - drug effects Cells, Cultured Humans Intercellular Adhesion Molecule-1 - metabolism Lymphocyte Function-Associated Antigen-1 - metabolism Magnetic Resonance Spectroscopy Streptomyces Streptomyces - chemistry Streptomyces - metabolism |
| title | Adxanthromycin: a new inhibitor of ICAM-1/LFA-1 mediated cell adhesion from Streptomyces sp. NA-148 |
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