Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: Results of a randomized, double-blind, placebo-controlled crossover study
Previous studies indicate that low dose bendrofluazide (1.25 mg/day) has no deleterious effect on insulin sensitivity in contrast to conventional doses. To evaluate the antihypertensive effect of 1.25 mg bendrofluazide across 24 h, we studied 12 subjects in a randomized, double blind, cross-over tri...
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| Veröffentlicht in: | American journal of hypertension 1999-05, Vol.12 (5), p.528-531 |
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| container_issue | 5 |
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| container_title | American journal of hypertension |
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| creator | Wiggam, M.Ivan Bell, Patrick M Sheridan, Brian Walmsley, Anona Atkinson, A.Brew |
| description | Previous studies indicate that low dose bendrofluazide (1.25 mg/day) has no deleterious effect on insulin sensitivity in contrast to conventional doses. To evaluate the antihypertensive effect of 1.25 mg bendrofluazide across 24 h, we studied 12 subjects in a randomized, double blind, cross-over trial, comprising 8 weeks of either 1.25 mg/day bendrofluazide or placebo. Twenty-four-hour blood pressure averages were significantly lower after bendrofluazide compared with placebo (systolic 125
± 4 v 136
± 3 mm Hg,
P
< .005; diastolic: 78
± 2
v 85
± 2 mm Hg,
P
< .01). Trough:peak ratios were 0.67
± 0.07 for systolic and 0.72
± 0.15 for diastolic blood pressure reduction. In conclusion, 1.25 mg bendrofluazide daily produced a useful antihypertensive effect across the full 24-h period. |
| doi_str_mv | 10.1016/S0895-7061(98)00268-4 |
| format | Article |
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± 4 v 136
± 3 mm Hg,
P
< .005; diastolic: 78
± 2
v 85
± 2 mm Hg,
P
< .01). Trough:peak ratios were 0.67
± 0.07 for systolic and 0.72
± 0.15 for diastolic blood pressure reduction. In conclusion, 1.25 mg bendrofluazide daily produced a useful antihypertensive effect across the full 24-h period.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1016/S0895-7061(98)00268-4</identifier><identifier>PMID: 10342793</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; ambulatory blood pressure monitoring ; Antihypertensive agents ; Antihypertensive Agents - administration & dosage ; bendrofluazide ; Bendroflumethiazide - administration & dosage ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure Monitoring, Ambulatory ; Cardiovascular system ; Circadian Rhythm - physiology ; Cross-Over Studies ; Double-Blind Method ; Follow-Up Studies ; Humans ; hypertension ; Hypertension - drug therapy ; Hypertension - physiopathology ; Medical sciences ; Pharmacology. Drug treatments ; Thiazide diuretics ; Treatment Outcome</subject><ispartof>American journal of hypertension, 1999-05, Vol.12 (5), p.528-531</ispartof><rights>1999 American Journal of Hypertension, Ltd.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-3059880054c0e2f6709cdfdf4cb278923b75a13b9d52465994965ae6f30e72153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1833608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10342793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiggam, M.Ivan</creatorcontrib><creatorcontrib>Bell, Patrick M</creatorcontrib><creatorcontrib>Sheridan, Brian</creatorcontrib><creatorcontrib>Walmsley, Anona</creatorcontrib><creatorcontrib>Atkinson, A.Brew</creatorcontrib><title>Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: Results of a randomized, double-blind, placebo-controlled crossover study</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Previous studies indicate that low dose bendrofluazide (1.25 mg/day) has no deleterious effect on insulin sensitivity in contrast to conventional doses. To evaluate the antihypertensive effect of 1.25 mg bendrofluazide across 24 h, we studied 12 subjects in a randomized, double blind, cross-over trial, comprising 8 weeks of either 1.25 mg/day bendrofluazide or placebo. Twenty-four-hour blood pressure averages were significantly lower after bendrofluazide compared with placebo (systolic 125
± 4 v 136
± 3 mm Hg,
P
< .005; diastolic: 78
± 2
v 85
± 2 mm Hg,
P
< .01). Trough:peak ratios were 0.67
± 0.07 for systolic and 0.72
± 0.15 for diastolic blood pressure reduction. In conclusion, 1.25 mg bendrofluazide daily produced a useful antihypertensive effect across the full 24-h period.</description><subject>Aged</subject><subject>ambulatory blood pressure monitoring</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>bendrofluazide</subject><subject>Bendroflumethiazide - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Cardiovascular system</subject><subject>Circadian Rhythm - physiology</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Thiazide diuretics</subject><subject>Treatment Outcome</subject><issn>0895-7061</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFDEUhoMoTjv6CEoWIjNgjUnlUokbkcEbNAhe1iGVnGgkVWmTqh56nmQed2q6G3Xn6nDgOxf-D6GnlFxQQuWrr0Rp0XRE0jOtzglppWr4PbSiqtMN1UTcR6s_yAl6VOsvQgiXkj5EJ5Qw3naardDNOl9hnyvgHkZfckizvY4e8Bm9aAUefpxjCAHcFLeQdjjlKygV9ylnjzcFap0L4LyFgluOf77GX6DOaao4B2xxsaPPQ7wG_3K5MfcJmj7Fcek2yTroc-PyOJWcEnjsSq51v6lOs989Rg-CTRWeHOsp-v7-3bfLj83684dPl2_XjeOsmxpGhFaKEMEdgTbIjmjngw_c9W2ndMv6TljKeu1Fy6XQmmspLMjACHQtFewUvTjs3ZT8e4Y6mSFWBynZEfJcjdSdIprLBRQHcP9ogWA2JQ627Awl5k6J2Ssxd3kbrcxeieHL3LPjgbkfwP8zdXCwAM-PgK3OprCk5mL9yynGJFEL9uaAwZLGNkIx1UUYHfhYFj_G5_ifT24BPfaojw</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Wiggam, M.Ivan</creator><creator>Bell, Patrick M</creator><creator>Sheridan, Brian</creator><creator>Walmsley, Anona</creator><creator>Atkinson, A.Brew</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: Results of a randomized, double-blind, placebo-controlled crossover study</title><author>Wiggam, M.Ivan ; Bell, Patrick M ; Sheridan, Brian ; Walmsley, Anona ; Atkinson, A.Brew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-3059880054c0e2f6709cdfdf4cb278923b75a13b9d52465994965ae6f30e72153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>ambulatory blood pressure monitoring</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>bendrofluazide</topic><topic>Bendroflumethiazide - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Cardiovascular system</topic><topic>Circadian Rhythm - physiology</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Thiazide diuretics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiggam, M.Ivan</creatorcontrib><creatorcontrib>Bell, Patrick M</creatorcontrib><creatorcontrib>Sheridan, Brian</creatorcontrib><creatorcontrib>Walmsley, Anona</creatorcontrib><creatorcontrib>Atkinson, A.Brew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiggam, M.Ivan</au><au>Bell, Patrick M</au><au>Sheridan, Brian</au><au>Walmsley, Anona</au><au>Atkinson, A.Brew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: Results of a randomized, double-blind, placebo-controlled crossover study</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>12</volume><issue>5</issue><spage>528</spage><epage>531</epage><pages>528-531</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><abstract>Previous studies indicate that low dose bendrofluazide (1.25 mg/day) has no deleterious effect on insulin sensitivity in contrast to conventional doses. To evaluate the antihypertensive effect of 1.25 mg bendrofluazide across 24 h, we studied 12 subjects in a randomized, double blind, cross-over trial, comprising 8 weeks of either 1.25 mg/day bendrofluazide or placebo. Twenty-four-hour blood pressure averages were significantly lower after bendrofluazide compared with placebo (systolic 125
± 4 v 136
± 3 mm Hg,
P
< .005; diastolic: 78
± 2
v 85
± 2 mm Hg,
P
< .01). Trough:peak ratios were 0.67
± 0.07 for systolic and 0.72
± 0.15 for diastolic blood pressure reduction. In conclusion, 1.25 mg bendrofluazide daily produced a useful antihypertensive effect across the full 24-h period.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10342793</pmid><doi>10.1016/S0895-7061(98)00268-4</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 1999-05, Vol.12 (5), p.528-531 |
| issn | 0895-7061 1879-1905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69780946 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged ambulatory blood pressure monitoring Antihypertensive agents Antihypertensive Agents - administration & dosage bendrofluazide Bendroflumethiazide - administration & dosage Biological and medical sciences Blood Pressure - drug effects Blood Pressure Monitoring, Ambulatory Cardiovascular system Circadian Rhythm - physiology Cross-Over Studies Double-Blind Method Follow-Up Studies Humans hypertension Hypertension - drug therapy Hypertension - physiopathology Medical sciences Pharmacology. Drug treatments Thiazide diuretics Treatment Outcome |
| title | Low dose bendrofluazide (1.25 mg) effectively lowers blood pressure over 24 h: Results of a randomized, double-blind, placebo-controlled crossover study |
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