Effects of Eyelid scrubbing on the lid margin
To compare the effects of eyelid scrubbing with an eyelid cleansing solution (ECS) to eyelid scrubbing with ECS and the addition of antibacterial or anti-inflammatory pharmaceuticals on the clinical appearance, microbial status, tissue histology, and the inflammatory cell profile of the normal eyeli...
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| Veröffentlicht in: | The CLAO journal 1999-04, Vol.25 (2), p.109-113 |
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| container_title | The CLAO journal |
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| creator | GREINER, J. V LEAHY, C. D GLONEK, T HEARN, S. L AUERBACH, D DAVIES, L |
| description | To compare the effects of eyelid scrubbing with an eyelid cleansing solution (ECS) to eyelid scrubbing with ECS and the addition of antibacterial or anti-inflammatory pharmaceuticals on the clinical appearance, microbial status, tissue histology, and the inflammatory cell profile of the normal eyelid margin.
Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 rabbits with clinically normal eyelids.
Significant hyperemia of the margin occurred in all three groups over the 3 week period; however, the degree of hyperemia was less with ECS+ (P |
| format | Article |
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Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 rabbits with clinically normal eyelids.
Significant hyperemia of the margin occurred in all three groups over the 3 week period; however, the degree of hyperemia was less with ECS+ (P<0.05) and ECS++ (P<0.05). Chemosis, tearing, mucus discharge, and the microbial status were not significantly different than controls. There were no marked histologic differences in the tissues, except for increased red blood cell packing in the small vessels near the lid margins in scrubbed eyelids, consistent with hyperemia. The inflammatory cell profile showed minimal changes that were not statistically significant in any of the three groups, except that >50% of mast cells showed evidence of degranulation.
Use of ECS with an antibiotic, or an antibiotic and steroid solution, resulted in less inflammation than scrubbing with ECS alone.</description><identifier>ISSN: 0733-8902</identifier><identifier>EISSN: 1538-0181</identifier><identifier>PMID: 10344297</identifier><identifier>CODEN: CLAJEU</identifier><language>eng</language><publisher>New York, NY: Kellner/McCaffery</publisher><subject>Administration, Topical ; Animals ; Anti-Infective Agents, Local - administration & dosage ; Biological and medical sciences ; Blepharitis - drug therapy ; Blepharitis - etiology ; Blepharitis - pathology ; Cell Count ; Contact Lenses - adverse effects ; Drug Combinations ; Eye ; Eyelids - drug effects ; Eyelids - pathology ; Follow-Up Studies ; Medical sciences ; Pharmacology. Drug treatments ; Prednisolone - administration & dosage ; Prednisolone - analogs & derivatives ; Rabbits ; Sulfacetamide - administration & dosage ; Surface-Active Agents - administration & dosage</subject><ispartof>The CLAO journal, 1999-04, Vol.25 (2), p.109-113</ispartof><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1779864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10344297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GREINER, J. V</creatorcontrib><creatorcontrib>LEAHY, C. D</creatorcontrib><creatorcontrib>GLONEK, T</creatorcontrib><creatorcontrib>HEARN, S. L</creatorcontrib><creatorcontrib>AUERBACH, D</creatorcontrib><creatorcontrib>DAVIES, L</creatorcontrib><title>Effects of Eyelid scrubbing on the lid margin</title><title>The CLAO journal</title><addtitle>CLAO J</addtitle><description>To compare the effects of eyelid scrubbing with an eyelid cleansing solution (ECS) to eyelid scrubbing with ECS and the addition of antibacterial or anti-inflammatory pharmaceuticals on the clinical appearance, microbial status, tissue histology, and the inflammatory cell profile of the normal eyelid margin.
Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 rabbits with clinically normal eyelids.
Significant hyperemia of the margin occurred in all three groups over the 3 week period; however, the degree of hyperemia was less with ECS+ (P<0.05) and ECS++ (P<0.05). Chemosis, tearing, mucus discharge, and the microbial status were not significantly different than controls. There were no marked histologic differences in the tissues, except for increased red blood cell packing in the small vessels near the lid margins in scrubbed eyelids, consistent with hyperemia. The inflammatory cell profile showed minimal changes that were not statistically significant in any of the three groups, except that >50% of mast cells showed evidence of degranulation.
Use of ECS with an antibiotic, or an antibiotic and steroid solution, resulted in less inflammation than scrubbing with ECS alone.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blepharitis - drug therapy</subject><subject>Blepharitis - etiology</subject><subject>Blepharitis - pathology</subject><subject>Cell Count</subject><subject>Contact Lenses - adverse effects</subject><subject>Drug Combinations</subject><subject>Eye</subject><subject>Eyelids - drug effects</subject><subject>Eyelids - pathology</subject><subject>Follow-Up Studies</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - analogs & derivatives</subject><subject>Rabbits</subject><subject>Sulfacetamide - administration & dosage</subject><subject>Surface-Active Agents - administration & dosage</subject><issn>0733-8902</issn><issn>1538-0181</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LxDAQBuAgiruu_gXJQbwFJpk2H0dZ6gcseNFzSdNkjfTLpj3sv7diReYw8PIwvHNGtjxHzYBrfk62oBCZNiA25CqlTwCxjLokGw6YZcKoLWFFCN5NifaBFiffxJomN85VFbsj7Ts6fXj6E7Z2PMbumlwE2yR_s-4deX8s3vbP7PD69LJ_OLCB53xiWTAqVwaFDBKMtlL4WgYBkAdRofacI2ohBdQcQYTKZK7myhnQKDCHCnfk_vfuMPZfs09T2cbkfNPYzvdzKqVRGgzkC7xd4Vy1vi6HMS5NT-Xfgwu4W4FNzjZhtJ2L6d8pZbTM8BuVX1ai</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>GREINER, J. V</creator><creator>LEAHY, C. D</creator><creator>GLONEK, T</creator><creator>HEARN, S. L</creator><creator>AUERBACH, D</creator><creator>DAVIES, L</creator><general>Kellner/McCaffery</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>Effects of Eyelid scrubbing on the lid margin</title><author>GREINER, J. V ; LEAHY, C. D ; GLONEK, T ; HEARN, S. L ; AUERBACH, D ; DAVIES, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p151t-4f97579326f6098a62ed6f2005f2b38e113382620d1302fb94cd17c90832350b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blepharitis - drug therapy</topic><topic>Blepharitis - etiology</topic><topic>Blepharitis - pathology</topic><topic>Cell Count</topic><topic>Contact Lenses - adverse effects</topic><topic>Drug Combinations</topic><topic>Eye</topic><topic>Eyelids - drug effects</topic><topic>Eyelids - pathology</topic><topic>Follow-Up Studies</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - analogs & derivatives</topic><topic>Rabbits</topic><topic>Sulfacetamide - administration & dosage</topic><topic>Surface-Active Agents - administration & dosage</topic><toplevel>online_resources</toplevel><creatorcontrib>GREINER, J. V</creatorcontrib><creatorcontrib>LEAHY, C. D</creatorcontrib><creatorcontrib>GLONEK, T</creatorcontrib><creatorcontrib>HEARN, S. L</creatorcontrib><creatorcontrib>AUERBACH, D</creatorcontrib><creatorcontrib>DAVIES, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The CLAO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GREINER, J. V</au><au>LEAHY, C. D</au><au>GLONEK, T</au><au>HEARN, S. L</au><au>AUERBACH, D</au><au>DAVIES, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Eyelid scrubbing on the lid margin</atitle><jtitle>The CLAO journal</jtitle><addtitle>CLAO J</addtitle><date>1999-04</date><risdate>1999</risdate><volume>25</volume><issue>2</issue><spage>109</spage><epage>113</epage><pages>109-113</pages><issn>0733-8902</issn><eissn>1538-0181</eissn><coden>CLAJEU</coden><abstract>To compare the effects of eyelid scrubbing with an eyelid cleansing solution (ECS) to eyelid scrubbing with ECS and the addition of antibacterial or anti-inflammatory pharmaceuticals on the clinical appearance, microbial status, tissue histology, and the inflammatory cell profile of the normal eyelid margin.
Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 rabbits with clinically normal eyelids.
Significant hyperemia of the margin occurred in all three groups over the 3 week period; however, the degree of hyperemia was less with ECS+ (P<0.05) and ECS++ (P<0.05). Chemosis, tearing, mucus discharge, and the microbial status were not significantly different than controls. There were no marked histologic differences in the tissues, except for increased red blood cell packing in the small vessels near the lid margins in scrubbed eyelids, consistent with hyperemia. The inflammatory cell profile showed minimal changes that were not statistically significant in any of the three groups, except that >50% of mast cells showed evidence of degranulation.
Use of ECS with an antibiotic, or an antibiotic and steroid solution, resulted in less inflammation than scrubbing with ECS alone.</abstract><cop>New York, NY</cop><pub>Kellner/McCaffery</pub><pmid>10344297</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0733-8902 |
| ispartof | The CLAO journal, 1999-04, Vol.25 (2), p.109-113 |
| issn | 0733-8902 1538-0181 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Topical Animals Anti-Infective Agents, Local - administration & dosage Biological and medical sciences Blepharitis - drug therapy Blepharitis - etiology Blepharitis - pathology Cell Count Contact Lenses - adverse effects Drug Combinations Eye Eyelids - drug effects Eyelids - pathology Follow-Up Studies Medical sciences Pharmacology. Drug treatments Prednisolone - administration & dosage Prednisolone - analogs & derivatives Rabbits Sulfacetamide - administration & dosage Surface-Active Agents - administration & dosage |
| title | Effects of Eyelid scrubbing on the lid margin |
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