DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals

The phenomenon by which irradiated cells influence non-irradiated neighboring cells, referred to as the bystander effect (BSE), is not well understood in terms of the underlying pathways involved. We sought to enlighten connections between DNA damage repair and the BSE. Utilizing sister chromatid ex...

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Veröffentlicht in:	Oncogene 2008-11, Vol.27 (53), p.6761-6769
Hauptverfasser:	Hagelstrom, R T, Askin, K F, Williams, A J, Ramaiah, L, Desaintes, C, Goodwin, E H, Ullrich, R L, Bailey, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Ataxia Ataxia telangiectasia Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Bystander Effect - radiation effects Cancer Cell Biology Cell Cycle Proteins - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cellular biology Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects DNA repair DNA Repair - radiation effects DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - metabolism DNA-dependent protein kinase Female Fundamental and applied biological sciences. Psychology Gamma Rays Genetic aspects Genetics Human Genetics Humans Influence Internal Medicine Ionizing radiation Kinases Male Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, SCID Molecular and cellular biology Oncology original-article Properties Protein kinase C Protein kinases Protein-Serine-Threonine Kinases - metabolism Radiation therapy Signal Transduction - radiation effects Sister chromatid exchange Tumor Suppressor Proteins - metabolism
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