Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution

Supraphysiological concentrations of recombinant activated factor VII (rVIIa, NovoSeven) are used to control bleeding in hemophilia. Current experimental evidence suggests that rVIIa may increase thrombin generation via two pathwaysone being tissue factor (TF)-dependent and another being activated p...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 2008-12, Vol.19 (8), p.743-755
Hauptverfasser:	Ovanesov, Mikhail V, Panteleev, Mikhail A, Sinauridze, Elena I, Kireev, Dmitry A, Plyushch, Olga P, Kopylov, Konstantin G, Lopatina, Elena G, Saenko, Evgueni L, Ataullakhanov, Fazoil I
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - drug effects Blood Platelets - cytology Blood Platelets - physiology Cell-Derived Microparticles Cells, Cultured Dose-Response Relationship, Drug Factor VIIa - pharmacology Fibrin - metabolism Hemophilia A - blood Humans Kinetics Recombinant Proteins - pharmacology Thrombin - metabolism Thromboplastin - pharmacology
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