Abnormalities of developmental cell death in Dad1‐deficient mice

Background Dad1, the defender against apoptotic cell death, comprises the oligosaccharyltransferase complex and is well conserved among eukaryotes. In hamster BHK21‐derived tsBN7 cells, loss of Dad1 causes apoptosis which cannot be prevented by Bcl‐2. Results To determine the role of Dad1 function i...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 1999-04, Vol.4 (4), p.243-252
Hauptverfasser:	Nishii, Kiyomasa, Tsuzuki, Teruhisa, Kumai, Madoka, Takeda, Naoki, Koga, Hideya, Aizawa, Shinichi, Nishimoto, Takeharu, Shibata, Yosaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins Blastocyst - physiology Cells, Cultured Crosses, Genetic Embryonic and Fetal Development Extremities - embryology Female Gene Deletion Gene Targeting Hexosyltransferases Male Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - physiology Mice Syndactyly - genetics Thymus Gland - pathology Transferases - metabolism
Online-Zugang:	Volltext
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