Feasibility of Diagnosing Subclinical Renal Allograft Rejection in Children By Whole Blood Gene Expression Analysis

Protocol biopsies are used to monitor allograft histology after transplantation. However, biopsy is an invasive procedure with potential complications, requires special facilities, and is unpractical for repeated monitoring of the graft. A noninvasive, robust, and rapid diagnostic method would be we...

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Veröffentlicht in:	Transplantation 2008-11, Vol.86 (9), p.1222-1228
Hauptverfasser:	ALAKULPPI, Noora, SEIKKU, Paula, JAATINEN, Taina, HOLMBERG, Christer, LAINE, Jarmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - metabolism Biological and medical sciences Biomarkers - blood Biopsy CD40 Ligand - genetics CD40 Ligand - metabolism Child Child, Preschool Feasibility Studies Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Graft Rejection - blood Graft Rejection - diagnosis Humans Inducible T-Cell Co-Stimulator Protein Infant Kidney - metabolism Kidney - pathology Kidney Transplantation Male Medical sciences Oligonucleotide Array Sequence Analysis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transplantation, Homologous
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