Investigation of terbinafine as a CYP2D6 inhibitor in vivo

Background Terbinafine is an orally active antifungal used in the treatment of dermatophytoses. To date, studies evaluating the effect of terbinafine on the cytochromes P450 have failed to show any significant interactions. This prospective open‐label study was designed to confirm our previous findi...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 1999-05, Vol.65 (5), p.465-472
Hauptverfasser:	Abdel‐Rahman, Susan M., Gotschall, R. Russell, Kauffman, Ralph E., Leeder, J. Steven, Kearns, Gregory L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antifungal Agents - pharmacology Antitussive Agents - administration & dosage Antitussive Agents - urine Chromatography, High Pressure Liquid Cytochrome P-450 CYP2D6 Inhibitors Dextromethorphan - administration & dosage Dextromethorphan - analogs & derivatives Dextromethorphan - urine Dextrorphan - urine Enzyme Inhibitors - pharmacology Female Humans Male Naphthalenes - pharmacology Phenotype Prospective Studies Reference Values Volunteers
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