Temperature Instability of ReNu With MoistureLoc: A New Theory to Explain the Worldwide Fusarium Keratitis Epidemic of 2004-2006
OBJECTIVE To investigate the effect of storage temperature on the ability of contact lens solutions to inhibit growth of Fusarium species. A 2006 Food and Drug Administration inspection of Bausch & Lomb's Greenville, South Carolina, manufacturing site indicated that Bausch & Lomb failed...
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| Veröffentlicht in: | Archives of ophthalmology (1960) 2008-11, Vol.126 (11), p.1493-1498 |
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| container_title | Archives of ophthalmology (1960) |
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| creator | Bullock, John D Warwar, Ronald E Elder, B. Laurel Northern, William I |
| description | OBJECTIVE To investigate the effect of storage temperature on the ability of contact lens solutions to inhibit growth of Fusarium species. A 2006 Food and Drug Administration inspection of Bausch & Lomb's Greenville, South Carolina, manufacturing site indicated that Bausch & Lomb failed to regulate storage and transport temperatures of their products. METHODS Six contact lens solutions were studied: ReNu with MoistureLoc, ReNu MultiPlus, COMPLETE Moistureplus, AQuify, Clear Care, and OPTI-FREE RepleniSH. Two bottles of each solution were separately stored at room temperature and 60°C for 4 weeks, serially diluted, and then tested for their ability to inhibit growth of 11 Fusarium isolates (7 of which were associated with the keratitis epidemic). RESULTS ReNu with MoistureLoc demonstrated the greatest decline in efficacy after 60°C storage. Clear Care and ReNu MultiPlus performed the best. Regarding the keratitis epidemic isolates only, the ReNu with MoistureLoc bottle stored at room temperature allowed growth in 27 of 84 combinations vs 67 of 84 combinations with the 60°C-stored bottle. CONCLUSIONS When exposed to prolonged temperature elevation, ReNu with MoistureLoc loses its in vitro fungistatic activity to a much greater extent than other products. Improper temperature control of ReNu with MoistureLoc may have contributed to the Fusarium keratitis epidemic of 2004-2006.Arch Ophthalmol. 2008;126(11):1493-1498--> |
| doi_str_mv | 10.1001/archopht.126.11.1493 |
| format | Article |
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Laurel ; Northern, William I</creator><creatorcontrib>Bullock, John D ; Warwar, Ronald E ; Elder, B. Laurel ; Northern, William I</creatorcontrib><description>OBJECTIVE To investigate the effect of storage temperature on the ability of contact lens solutions to inhibit growth of Fusarium species. A 2006 Food and Drug Administration inspection of Bausch & Lomb's Greenville, South Carolina, manufacturing site indicated that Bausch & Lomb failed to regulate storage and transport temperatures of their products. METHODS Six contact lens solutions were studied: ReNu with MoistureLoc, ReNu MultiPlus, COMPLETE Moistureplus, AQuify, Clear Care, and OPTI-FREE RepleniSH. Two bottles of each solution were separately stored at room temperature and 60°C for 4 weeks, serially diluted, and then tested for their ability to inhibit growth of 11 Fusarium isolates (7 of which were associated with the keratitis epidemic). RESULTS ReNu with MoistureLoc demonstrated the greatest decline in efficacy after 60°C storage. Clear Care and ReNu MultiPlus performed the best. Regarding the keratitis epidemic isolates only, the ReNu with MoistureLoc bottle stored at room temperature allowed growth in 27 of 84 combinations vs 67 of 84 combinations with the 60°C-stored bottle. CONCLUSIONS When exposed to prolonged temperature elevation, ReNu with MoistureLoc loses its in vitro fungistatic activity to a much greater extent than other products. Improper temperature control of ReNu with MoistureLoc may have contributed to the Fusarium keratitis epidemic of 2004-2006.Arch Ophthalmol. 2008;126(11):1493-1498--></description><identifier>ISSN: 0003-9950</identifier><identifier>ISSN: 2168-6165</identifier><identifier>EISSN: 1538-3601</identifier><identifier>EISSN: 2168-6173</identifier><identifier>DOI: 10.1001/archopht.126.11.1493</identifier><identifier>PMID: 19001215</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Biological and medical sciences ; Contact Lens Solutions - pharmacology ; Contact lenses ; Contact Lenses - microbiology ; Diseases of cornea, anterior segment and sclera ; Disinfection - standards ; Drug Storage - methods ; Effects ; Eye Infections, Fungal - epidemiology ; Eye Infections, Fungal - microbiology ; Fungi ; Fusarium - drug effects ; Fusarium - growth & development ; Hot Temperature ; Humans ; Keratitis - epidemiology ; Keratitis - microbiology ; Medical sciences ; Miscellaneous ; Mycoses - epidemiology ; Mycoses - microbiology ; Ophthalmology ; Pilot Projects ; Storage ; Temperature ; Transportation</subject><ispartof>Archives of ophthalmology (1960), 2008-11, Vol.126 (11), p.1493-1498</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright American Medical Association Nov 2008</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20849957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19001215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bullock, John D</creatorcontrib><creatorcontrib>Warwar, Ronald E</creatorcontrib><creatorcontrib>Elder, B. Laurel</creatorcontrib><creatorcontrib>Northern, William I</creatorcontrib><title>Temperature Instability of ReNu With MoistureLoc: A New Theory to Explain the Worldwide Fusarium Keratitis Epidemic of 2004-2006</title><title>Archives of ophthalmology (1960)</title><addtitle>Arch Ophthalmol</addtitle><description>OBJECTIVE To investigate the effect of storage temperature on the ability of contact lens solutions to inhibit growth of Fusarium species. A 2006 Food and Drug Administration inspection of Bausch & Lomb's Greenville, South Carolina, manufacturing site indicated that Bausch & Lomb failed to regulate storage and transport temperatures of their products. METHODS Six contact lens solutions were studied: ReNu with MoistureLoc, ReNu MultiPlus, COMPLETE Moistureplus, AQuify, Clear Care, and OPTI-FREE RepleniSH. Two bottles of each solution were separately stored at room temperature and 60°C for 4 weeks, serially diluted, and then tested for their ability to inhibit growth of 11 Fusarium isolates (7 of which were associated with the keratitis epidemic). RESULTS ReNu with MoistureLoc demonstrated the greatest decline in efficacy after 60°C storage. Clear Care and ReNu MultiPlus performed the best. Regarding the keratitis epidemic isolates only, the ReNu with MoistureLoc bottle stored at room temperature allowed growth in 27 of 84 combinations vs 67 of 84 combinations with the 60°C-stored bottle. CONCLUSIONS When exposed to prolonged temperature elevation, ReNu with MoistureLoc loses its in vitro fungistatic activity to a much greater extent than other products. Improper temperature control of ReNu with MoistureLoc may have contributed to the Fusarium keratitis epidemic of 2004-2006.Arch Ophthalmol. 2008;126(11):1493-1498--></description><subject>Biological and medical sciences</subject><subject>Contact Lens Solutions - pharmacology</subject><subject>Contact lenses</subject><subject>Contact Lenses - microbiology</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>Disinfection - standards</subject><subject>Drug Storage - methods</subject><subject>Effects</subject><subject>Eye Infections, Fungal - epidemiology</subject><subject>Eye Infections, Fungal - microbiology</subject><subject>Fungi</subject><subject>Fusarium - drug effects</subject><subject>Fusarium - growth & development</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Keratitis - epidemiology</subject><subject>Keratitis - microbiology</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mycoses - epidemiology</subject><subject>Mycoses - microbiology</subject><subject>Ophthalmology</subject><subject>Pilot Projects</subject><subject>Storage</subject><subject>Temperature</subject><subject>Transportation</subject><issn>0003-9950</issn><issn>2168-6165</issn><issn>1538-3601</issn><issn>2168-6173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVGL1DAQx4Mo3nr6AQSRIOhb10ySplvfjmNPD9cTZOUeQ5KmNEfb9JKUc9_86KbseoIvE4b5zT8DP4TeAFkDIfBRBdP5qUtroGINsAZesydoBSXbFEwQeIpWhBBW1HVJztCLGO9yK4DUz9EZ1DmBQrlCv_d2mGxQaQ4WX48xKe16lw7Yt_iHvZnxrUsd_uZdXIidN5_wBb6xD3jfWR8OOHm8_TX1yo04dRbf-tA3D66x-GqOKrh5wF-XdJdcxNspDwZnlmxKCC9yES_Rs1b10b46vefo59V2f_ml2H3_fH15sSsU5TwVhnDDq3y-LRnjommb0m408MqWvNZaaFK2LdGsAdPqTQNV02xEowm3hmlhBTtHH465U_D3s41JDi4a2_dqtH6OUtRVVXIOGXz3H3jn5zDm2yRlUJdU0CpD_AiZ4GMMtpVTcIMKBwlELnrkXz0y65EActGT196esmc92Obf0slHBt6fABWN6tugRuPiI0fJhmefy_-vj5wa1OOUU6gFZX8AS0eiHA</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Bullock, John D</creator><creator>Warwar, Ronald E</creator><creator>Elder, B. 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Laurel ; Northern, William I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a244t-c04c47610e53346dfd5e8b147e549bb6b05ff0b3d1cfb8d17dd86db04ec3b6e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Contact Lens Solutions - pharmacology</topic><topic>Contact lenses</topic><topic>Contact Lenses - microbiology</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>Disinfection - standards</topic><topic>Drug Storage - methods</topic><topic>Effects</topic><topic>Eye Infections, Fungal - epidemiology</topic><topic>Eye Infections, Fungal - microbiology</topic><topic>Fungi</topic><topic>Fusarium - drug effects</topic><topic>Fusarium - growth & development</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Keratitis - epidemiology</topic><topic>Keratitis - microbiology</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mycoses - epidemiology</topic><topic>Mycoses - microbiology</topic><topic>Ophthalmology</topic><topic>Pilot Projects</topic><topic>Storage</topic><topic>Temperature</topic><topic>Transportation</topic><toplevel>online_resources</toplevel><creatorcontrib>Bullock, John D</creatorcontrib><creatorcontrib>Warwar, Ronald E</creatorcontrib><creatorcontrib>Elder, B. Laurel</creatorcontrib><creatorcontrib>Northern, William I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of ophthalmology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bullock, John D</au><au>Warwar, Ronald E</au><au>Elder, B. Laurel</au><au>Northern, William I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature Instability of ReNu With MoistureLoc: A New Theory to Explain the Worldwide Fusarium Keratitis Epidemic of 2004-2006</atitle><jtitle>Archives of ophthalmology (1960)</jtitle><addtitle>Arch Ophthalmol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>126</volume><issue>11</issue><spage>1493</spage><epage>1498</epage><pages>1493-1498</pages><issn>0003-9950</issn><issn>2168-6165</issn><eissn>1538-3601</eissn><eissn>2168-6173</eissn><abstract>OBJECTIVE To investigate the effect of storage temperature on the ability of contact lens solutions to inhibit growth of Fusarium species. A 2006 Food and Drug Administration inspection of Bausch & Lomb's Greenville, South Carolina, manufacturing site indicated that Bausch & Lomb failed to regulate storage and transport temperatures of their products. METHODS Six contact lens solutions were studied: ReNu with MoistureLoc, ReNu MultiPlus, COMPLETE Moistureplus, AQuify, Clear Care, and OPTI-FREE RepleniSH. Two bottles of each solution were separately stored at room temperature and 60°C for 4 weeks, serially diluted, and then tested for their ability to inhibit growth of 11 Fusarium isolates (7 of which were associated with the keratitis epidemic). RESULTS ReNu with MoistureLoc demonstrated the greatest decline in efficacy after 60°C storage. Clear Care and ReNu MultiPlus performed the best. Regarding the keratitis epidemic isolates only, the ReNu with MoistureLoc bottle stored at room temperature allowed growth in 27 of 84 combinations vs 67 of 84 combinations with the 60°C-stored bottle. CONCLUSIONS When exposed to prolonged temperature elevation, ReNu with MoistureLoc loses its in vitro fungistatic activity to a much greater extent than other products. Improper temperature control of ReNu with MoistureLoc may have contributed to the Fusarium keratitis epidemic of 2004-2006.Arch Ophthalmol. 2008;126(11):1493-1498--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>19001215</pmid><doi>10.1001/archopht.126.11.1493</doi><tpages>6</tpages></addata></record> |
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| ispartof | Archives of ophthalmology (1960), 2008-11, Vol.126 (11), p.1493-1498 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Contact Lens Solutions - pharmacology Contact lenses Contact Lenses - microbiology Diseases of cornea, anterior segment and sclera Disinfection - standards Drug Storage - methods Effects Eye Infections, Fungal - epidemiology Eye Infections, Fungal - microbiology Fungi Fusarium - drug effects Fusarium - growth & development Hot Temperature Humans Keratitis - epidemiology Keratitis - microbiology Medical sciences Miscellaneous Mycoses - epidemiology Mycoses - microbiology Ophthalmology Pilot Projects Storage Temperature Transportation |
| title | Temperature Instability of ReNu With MoistureLoc: A New Theory to Explain the Worldwide Fusarium Keratitis Epidemic of 2004-2006 |
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