Activation of the Leukocyte NADPH Oxidase by Protein Kinase C in a Partially Recombinant Cell-free System

The leukocyte NADPH oxidase is an enzyme present in phagocytes and B lymphocytes that when activated catalyzes the production of O⨪2 from oxygen at the expense of NADPH. A correlation between the activation of the oxidase and the phosphorylation of p47 PHOX, a cytosolic oxidase component, is well re...

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Veröffentlicht in:	The Journal of biological chemistry 1999-05, Vol.274 (22), p.15533-15537
Hauptverfasser:	Lopes, Lucia Rossetti, Hoyal, Carolyn R., Knaus, Ulla G., Babior, Bernard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell-Free System Cytochrome b Group - metabolism Cytochrome c Group - metabolism Cytosol - metabolism Enzyme Activation GTP-Binding Proteins - metabolism Guanosine Diphosphate - metabolism Guanosine Triphosphate - metabolism Humans Leukocytes - enzymology NADPH Oxidases - metabolism Neutrophils - enzymology Neutrophils - metabolism Phosphoproteins - metabolism Phosphorylation Protein Kinase C - metabolism rac GTP-Binding Proteins Reactive Oxygen Species - metabolism Recombinant Proteins - metabolism Sodium Dodecyl Sulfate - pharmacology
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