Benzodiazepine Receptor Function in the Chick Social Separation-Stress Procedure
The role of benzodiazepine (BZ) receptors in modulating social separation-induced distress vocalizations (DVocs) and stress-induced analgesia (SIA) were examined in 8-day-old cockerels ( Gallus gallus ). In Experiment 1, the BZ agonist chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in...
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| Veröffentlicht in: | Experimental and clinical psychopharmacology 1999-05, Vol.7 (2), p.83-89 |
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| creator | Watson, G. Stennis Roach, J. Todd Sufka, Kenneth J |
| description | The role of benzodiazepine (BZ) receptors in modulating
social separation-induced distress vocalizations (DVocs) and
stress-induced analgesia (SIA) were examined in 8-day-old cockerels
(
Gallus gallus
). In Experiment 1, the BZ agonist
chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in
isolated chicks. Coadministration of the BZ antagonist flumazenil
(0.01, 0.03, or 0.10 mg/kg) reversed CDP anxiolytic effects. In
Experiment 2, the BZ agonists alprazolam (ALP; 0.065, 0.125, 0.25, or 0.50 mg/kg) and lorazepam (LOR; 0.125, 0.25, 0.50, or 1.0 mg/kg)
dose dependently reversed social separation-induced DVocs and
SIA. The ED
50
s for ALP and LOR in attenuating DVocs
were 0.19 and 0.34 mg/kg, respectively. These data strongly support
the theory that CDP anxiolytic effects are mediated by BZ receptor
activity in the chick social separation procedure (Experiment 1) and
that this model is sensitive to BZ agonists of different potencies
(Experiment 2). |
| doi_str_mv | 10.1037/1064-1297.7.2.83 |
| format | Article |
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social separation-induced distress vocalizations (DVocs) and
stress-induced analgesia (SIA) were examined in 8-day-old cockerels
(
Gallus gallus
). In Experiment 1, the BZ agonist
chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in
isolated chicks. Coadministration of the BZ antagonist flumazenil
(0.01, 0.03, or 0.10 mg/kg) reversed CDP anxiolytic effects. In
Experiment 2, the BZ agonists alprazolam (ALP; 0.065, 0.125, 0.25, or 0.50 mg/kg) and lorazepam (LOR; 0.125, 0.25, 0.50, or 1.0 mg/kg)
dose dependently reversed social separation-induced DVocs and
SIA. The ED
50
s for ALP and LOR in attenuating DVocs
were 0.19 and 0.34 mg/kg, respectively. These data strongly support
the theory that CDP anxiolytic effects are mediated by BZ receptor
activity in the chick social separation procedure (Experiment 1) and
that this model is sensitive to BZ agonists of different potencies
(Experiment 2).</description><identifier>ISSN: 1064-1297</identifier><identifier>EISSN: 1936-2293</identifier><identifier>DOI: 10.1037/1064-1297.7.2.83</identifier><identifier>PMID: 10340149</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Alprazolam - therapeutic use ; Analgesia ; Analgesia - psychology ; Animal ; Animal Vocalizations ; Animals ; Anti-Anxiety Agents - pharmacology ; Benzodiazepine Agonists ; Benzodiazepine Antagonists ; Chickens ; Chlordiazepoxide - antagonists & inhibitors ; Chlordiazepoxide - pharmacology ; Disease Models, Animal ; Flumazenil - pharmacology ; GABA-A Receptor Agonists ; GABA-A Receptor Antagonists ; Infants (Animal) ; Lorazepam - therapeutic use ; Receptors, GABA-A - metabolism ; Separation Reactions ; Social Behavior ; Stress Reactions ; Stress, Psychological - drug therapy ; Stress, Psychological - metabolism</subject><ispartof>Experimental and clinical psychopharmacology, 1999-05, Vol.7 (2), p.83-89</ispartof><rights>1999 American Psychological Association</rights><rights>1999, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a349t-4fbecdbe083243614e68d5502755534dfe4b12ab5dbf79175ff3634d3db75c793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10340149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watson, G. Stennis</creatorcontrib><creatorcontrib>Roach, J. Todd</creatorcontrib><creatorcontrib>Sufka, Kenneth J</creatorcontrib><title>Benzodiazepine Receptor Function in the Chick Social Separation-Stress Procedure</title><title>Experimental and clinical psychopharmacology</title><addtitle>Exp Clin Psychopharmacol</addtitle><description>The role of benzodiazepine (BZ) receptors in modulating
social separation-induced distress vocalizations (DVocs) and
stress-induced analgesia (SIA) were examined in 8-day-old cockerels
(
Gallus gallus
). In Experiment 1, the BZ agonist
chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in
isolated chicks. Coadministration of the BZ antagonist flumazenil
(0.01, 0.03, or 0.10 mg/kg) reversed CDP anxiolytic effects. In
Experiment 2, the BZ agonists alprazolam (ALP; 0.065, 0.125, 0.25, or 0.50 mg/kg) and lorazepam (LOR; 0.125, 0.25, 0.50, or 1.0 mg/kg)
dose dependently reversed social separation-induced DVocs and
SIA. The ED
50
s for ALP and LOR in attenuating DVocs
were 0.19 and 0.34 mg/kg, respectively. These data strongly support
the theory that CDP anxiolytic effects are mediated by BZ receptor
activity in the chick social separation procedure (Experiment 1) and
that this model is sensitive to BZ agonists of different potencies
(Experiment 2).</description><subject>Alprazolam - therapeutic use</subject><subject>Analgesia</subject><subject>Analgesia - psychology</subject><subject>Animal</subject><subject>Animal Vocalizations</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Benzodiazepine Agonists</subject><subject>Benzodiazepine Antagonists</subject><subject>Chickens</subject><subject>Chlordiazepoxide - antagonists & inhibitors</subject><subject>Chlordiazepoxide - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Flumazenil - pharmacology</subject><subject>GABA-A Receptor Agonists</subject><subject>GABA-A Receptor Antagonists</subject><subject>Infants (Animal)</subject><subject>Lorazepam - therapeutic use</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Separation Reactions</subject><subject>Social Behavior</subject><subject>Stress Reactions</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - metabolism</subject><issn>1064-1297</issn><issn>1936-2293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUDtv2zAQJoIWTeJ0z1QIHbLJJXmkKI6tkUeBADXiZCYo6gQzlUWVlAbn14eGE7TodK_vcfgIuWR0ySiob4xWomRcq6Va8mUNJ-SMaahKzjV8yP37-ZScp_RMKROg-SdymskiD_qMrH_g8BJab19w9AMWD-hwnEIsbubBTT4MhR-KaYvFauvd72ITnLd9scHRRns4l5spYkrFOgaH7RzxgnzsbJ_w81tdkKeb68fVXXn_6_bn6vt9aUHoqRRdg65tkNbABVRMYFW3UlKupJQg2g5Fw7htZNt0SjMluw6qvIe2UdIpDQtyddQdY_gzY5rMzieHfW8HDHMylVZKUuAZ-PU_4HOY45B_M9kWQICoM4geQS6GlCJ2Zox-Z-PeMGoOUZtDluaQpVGGmxoy5cub7tzssP2HcMz2r7EdrRnT3tk4eddjMuPWvqu8AoLhhMk</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Watson, G. Stennis</creator><creator>Roach, J. Todd</creator><creator>Sufka, Kenneth J</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>Benzodiazepine Receptor Function in the Chick Social Separation-Stress Procedure</title><author>Watson, G. Stennis ; Roach, J. Todd ; Sufka, Kenneth J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a349t-4fbecdbe083243614e68d5502755534dfe4b12ab5dbf79175ff3634d3db75c793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alprazolam - therapeutic use</topic><topic>Analgesia</topic><topic>Analgesia - psychology</topic><topic>Animal</topic><topic>Animal Vocalizations</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Benzodiazepine Agonists</topic><topic>Benzodiazepine Antagonists</topic><topic>Chickens</topic><topic>Chlordiazepoxide - antagonists & inhibitors</topic><topic>Chlordiazepoxide - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Flumazenil - pharmacology</topic><topic>GABA-A Receptor Agonists</topic><topic>GABA-A Receptor Antagonists</topic><topic>Infants (Animal)</topic><topic>Lorazepam - therapeutic use</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Separation Reactions</topic><topic>Social Behavior</topic><topic>Stress Reactions</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watson, G. Stennis</creatorcontrib><creatorcontrib>Roach, J. Todd</creatorcontrib><creatorcontrib>Sufka, Kenneth J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watson, G. Stennis</au><au>Roach, J. Todd</au><au>Sufka, Kenneth J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzodiazepine Receptor Function in the Chick Social Separation-Stress Procedure</atitle><jtitle>Experimental and clinical psychopharmacology</jtitle><addtitle>Exp Clin Psychopharmacol</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>7</volume><issue>2</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>1064-1297</issn><eissn>1936-2293</eissn><abstract>The role of benzodiazepine (BZ) receptors in modulating
social separation-induced distress vocalizations (DVocs) and
stress-induced analgesia (SIA) were examined in 8-day-old cockerels
(
Gallus gallus
). In Experiment 1, the BZ agonist
chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in
isolated chicks. Coadministration of the BZ antagonist flumazenil
(0.01, 0.03, or 0.10 mg/kg) reversed CDP anxiolytic effects. In
Experiment 2, the BZ agonists alprazolam (ALP; 0.065, 0.125, 0.25, or 0.50 mg/kg) and lorazepam (LOR; 0.125, 0.25, 0.50, or 1.0 mg/kg)
dose dependently reversed social separation-induced DVocs and
SIA. The ED
50
s for ALP and LOR in attenuating DVocs
were 0.19 and 0.34 mg/kg, respectively. These data strongly support
the theory that CDP anxiolytic effects are mediated by BZ receptor
activity in the chick social separation procedure (Experiment 1) and
that this model is sensitive to BZ agonists of different potencies
(Experiment 2).</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>10340149</pmid><doi>10.1037/1064-1297.7.2.83</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Experimental and clinical psychopharmacology, 1999-05, Vol.7 (2), p.83-89 |
| issn | 1064-1297 1936-2293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69775032 |
| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Alprazolam - therapeutic use Analgesia Analgesia - psychology Animal Animal Vocalizations Animals Anti-Anxiety Agents - pharmacology Benzodiazepine Agonists Benzodiazepine Antagonists Chickens Chlordiazepoxide - antagonists & inhibitors Chlordiazepoxide - pharmacology Disease Models, Animal Flumazenil - pharmacology GABA-A Receptor Agonists GABA-A Receptor Antagonists Infants (Animal) Lorazepam - therapeutic use Receptors, GABA-A - metabolism Separation Reactions Social Behavior Stress Reactions Stress, Psychological - drug therapy Stress, Psychological - metabolism |
| title | Benzodiazepine Receptor Function in the Chick Social Separation-Stress Procedure |
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