Acute-phase reactans in Hashimoto thyroiditis
Hashimoto thyroiditis (HT) is one of the autoimmune diseases of the thyroid gland. It is characterized by diffuse lymphocytic infiltration of the thyroid gland and the elevated levels of the serum anti-thyroid antibodies. Recently Hashimoto thyroiditis has been proposed as a systemic disorder. Acute...
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| Veröffentlicht in: | International immunopharmacology 2008-12, Vol.8 (13), p.1863-1865 |
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| creator | Erden, Sacide Buyukozturk, Suna Vural, Pervin Değirmencioğlu, Sevgin |
| description | Hashimoto thyroiditis (HT) is one of the autoimmune diseases of the thyroid gland. It is characterized by diffuse lymphocytic infiltration of the thyroid gland and the elevated levels of the serum anti-thyroid antibodies. Recently Hashimoto thyroiditis has been proposed as a systemic disorder.
Acute-phase reactans have been implicated for their involvement as pro-inflammatory molecules in various inflammatory diseases. The aim of the present study was to examine the blood concentrations of acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in the patients with Hashimoto thyroiditis. Two groups were enrolled: study group consisting from euthyroid patients with HT (
n
=
30), and healthy control subjects (
n
=
30). Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA, fibrinogen, and ESR. Mean ESR was found to be higher in HT patients than control group (
p
=
0.024). The mean fibrinogen and SAA values in HT were also significantly higher than that of the control group (
p
=
0.03,
p
=
0.002). We therefore suggest that a low-grade systemic inflammation may exist in HT patients even if they were euthyroid. |
| doi_str_mv | 10.1016/j.intimp.2008.09.007 |
| format | Article |
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Acute-phase reactans have been implicated for their involvement as pro-inflammatory molecules in various inflammatory diseases. The aim of the present study was to examine the blood concentrations of acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in the patients with Hashimoto thyroiditis. Two groups were enrolled: study group consisting from euthyroid patients with HT (
n
=
30), and healthy control subjects (
n
=
30). Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA, fibrinogen, and ESR. Mean ESR was found to be higher in HT patients than control group (
p
=
0.024). The mean fibrinogen and SAA values in HT were also significantly higher than that of the control group (
p
=
0.03,
p
=
0.002). We therefore suggest that a low-grade systemic inflammation may exist in HT patients even if they were euthyroid.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2008.09.007</identifier><identifier>PMID: 18835463</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Acute-phase proteins ; Acute-Phase Reaction - immunology ; Adult ; Biological and medical sciences ; C-reactive protein ; C-Reactive Protein - analysis ; Endocrinopathies ; Female ; Fibrinogen ; Fibrinogen - analysis ; Hashimoto Disease - blood ; Hashimoto Disease - immunology ; Hashimoto thyroiditis ; Humans ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pharmacology. Drug treatments ; Serum amyloid A ; Serum Amyloid A Protein - analysis ; Systemic inflammation ; Thyroid. Thyroid axis (diseases)</subject><ispartof>International immunopharmacology, 2008-12, Vol.8 (13), p.1863-1865</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-8c2cdaedb9b7cbd93a2a7c23c1735c1cb8fb0828f9abd58a26f47e8ca51bb8603</citedby><cites>FETCH-LOGICAL-c421t-8c2cdaedb9b7cbd93a2a7c23c1735c1cb8fb0828f9abd58a26f47e8ca51bb8603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567576908002890$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20860460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18835463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erden, Sacide</creatorcontrib><creatorcontrib>Buyukozturk, Suna</creatorcontrib><creatorcontrib>Vural, Pervin</creatorcontrib><creatorcontrib>Değirmencioğlu, Sevgin</creatorcontrib><title>Acute-phase reactans in Hashimoto thyroiditis</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Hashimoto thyroiditis (HT) is one of the autoimmune diseases of the thyroid gland. It is characterized by diffuse lymphocytic infiltration of the thyroid gland and the elevated levels of the serum anti-thyroid antibodies. Recently Hashimoto thyroiditis has been proposed as a systemic disorder.
Acute-phase reactans have been implicated for their involvement as pro-inflammatory molecules in various inflammatory diseases. The aim of the present study was to examine the blood concentrations of acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in the patients with Hashimoto thyroiditis. Two groups were enrolled: study group consisting from euthyroid patients with HT (
n
=
30), and healthy control subjects (
n
=
30). Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA, fibrinogen, and ESR. Mean ESR was found to be higher in HT patients than control group (
p
=
0.024). The mean fibrinogen and SAA values in HT were also significantly higher than that of the control group (
p
=
0.03,
p
=
0.002). We therefore suggest that a low-grade systemic inflammation may exist in HT patients even if they were euthyroid.</description><subject>Acute-phase proteins</subject><subject>Acute-Phase Reaction - immunology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinogen - analysis</subject><subject>Hashimoto Disease - blood</subject><subject>Hashimoto Disease - immunology</subject><subject>Hashimoto thyroiditis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pharmacology. Drug treatments</subject><subject>Serum amyloid A</subject><subject>Serum Amyloid A Protein - analysis</subject><subject>Systemic inflammation</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_gUgvets1H7ub5CKUolYoeNFzSGazNGU_apIK_fdu3UVveppheGaY90HomuCUYFLcb1PXRtfsUoqxSLFMMeYnaEoEFwnhOD_t-7zgSc4LOUEXIWwx7ucZOUcTIgTLs4JNUbKAfbTJbqODnXurIeo2zF07X-mwcU0Xu3ncHHznShdduERnla6DvRrrDL0_Pb4tV8n69flluVgnkFESEwEUSm1LIw0HU0qmqeZAGRDOciBgRGWwoKKS2pS50LSoMm4F6JwYIwrMZuhuuLvz3cfehqgaF8DWtW5ttw-qkJwzXGT_gkQyTpnMezAbQPBdCN5Wauddo_1BEayOPtVWDT7V0afCUvU--7Wb8f7eNLb8XRoF9sDtCOgAuq68bsGFH47iPk72nehh4Gyv7dNZrwI424ItnbcQVdm5vz_5At0TlZ4</recordid><startdate>20081220</startdate><enddate>20081220</enddate><creator>Erden, Sacide</creator><creator>Buyukozturk, Suna</creator><creator>Vural, Pervin</creator><creator>Değirmencioğlu, Sevgin</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20081220</creationdate><title>Acute-phase reactans in Hashimoto thyroiditis</title><author>Erden, Sacide ; Buyukozturk, Suna ; Vural, Pervin ; Değirmencioğlu, Sevgin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-8c2cdaedb9b7cbd93a2a7c23c1735c1cb8fb0828f9abd58a26f47e8ca51bb8603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute-phase proteins</topic><topic>Acute-Phase Reaction - immunology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinogen - analysis</topic><topic>Hashimoto Disease - blood</topic><topic>Hashimoto Disease - immunology</topic><topic>Hashimoto thyroiditis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pharmacology. Drug treatments</topic><topic>Serum amyloid A</topic><topic>Serum Amyloid A Protein - analysis</topic><topic>Systemic inflammation</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erden, Sacide</creatorcontrib><creatorcontrib>Buyukozturk, Suna</creatorcontrib><creatorcontrib>Vural, Pervin</creatorcontrib><creatorcontrib>Değirmencioğlu, Sevgin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erden, Sacide</au><au>Buyukozturk, Suna</au><au>Vural, Pervin</au><au>Değirmencioğlu, Sevgin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute-phase reactans in Hashimoto thyroiditis</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2008-12-20</date><risdate>2008</risdate><volume>8</volume><issue>13</issue><spage>1863</spage><epage>1865</epage><pages>1863-1865</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Hashimoto thyroiditis (HT) is one of the autoimmune diseases of the thyroid gland. It is characterized by diffuse lymphocytic infiltration of the thyroid gland and the elevated levels of the serum anti-thyroid antibodies. Recently Hashimoto thyroiditis has been proposed as a systemic disorder.
Acute-phase reactans have been implicated for their involvement as pro-inflammatory molecules in various inflammatory diseases. The aim of the present study was to examine the blood concentrations of acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in the patients with Hashimoto thyroiditis. Two groups were enrolled: study group consisting from euthyroid patients with HT (
n
=
30), and healthy control subjects (
n
=
30). Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA, fibrinogen, and ESR. Mean ESR was found to be higher in HT patients than control group (
p
=
0.024). The mean fibrinogen and SAA values in HT were also significantly higher than that of the control group (
p
=
0.03,
p
=
0.002). We therefore suggest that a low-grade systemic inflammation may exist in HT patients even if they were euthyroid.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>18835463</pmid><doi>10.1016/j.intimp.2008.09.007</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute-phase proteins Acute-Phase Reaction - immunology Adult Biological and medical sciences C-reactive protein C-Reactive Protein - analysis Endocrinopathies Female Fibrinogen Fibrinogen - analysis Hashimoto Disease - blood Hashimoto Disease - immunology Hashimoto thyroiditis Humans Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Pharmacology. Drug treatments Serum amyloid A Serum Amyloid A Protein - analysis Systemic inflammation Thyroid. Thyroid axis (diseases) |
| title | Acute-phase reactans in Hashimoto thyroiditis |
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