Genetic association analysis: a primer on how it works, its strengths and its weaknesses

Summary Currently, the most used approach to mapping disease genes is the genome wide association study, using large samples of cases and controls and hundreds of thousands of markers spread throughout the genome. This review focuses in explaining how an association study works, its strengths and it...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of andrology 2008-12, Vol.31 (6), p.546-556
Hauptverfasser:	Rodriguez-Murillo, Laura, Greenberg, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	association analysis Biological and medical sciences Chromosomes, Human, Y - genetics False Positive Reactions Family Fundamental and applied biological sciences. Psychology Genetic Linkage Genetic Predisposition to Disease - genetics Genetics, Population - methods Genome-Wide Association Study - methods Gynecology. Andrology. Obstetrics Humans linkage disequilibrium Linkage Disequilibrium - genetics Male Male genital diseases Mammalian male genital system Medical sciences Phenotype Polymorphism, Single Nucleotide population stratification Principal Component Analysis single nucleotide polymorphisms Vertebrates: reproduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!