Three-Phase Bone Scintigraphy in Chronic Epicondylitis
Abstract Pienimäki TT, Takalo RJ, Ahonen AK, Karppinen JI. Three-phase bone scintigraphy in chronic epicondylitis. Objective To assess the utility of 3-phase bone scintigraphy as a complementary diagnostic method in chronic epicondylitis. Design A cross-sectional study. Setting Hospital outpatient c...
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| creator | Pienimäki, Tuomo T., MD, PhD Takalo, Reijo J., MD, PhD Ahonen, Aapo K., MD, PhD Karppinen, Jaro I., MD, PhD |
| description | Abstract Pienimäki TT, Takalo RJ, Ahonen AK, Karppinen JI. Three-phase bone scintigraphy in chronic epicondylitis. Objective To assess the utility of 3-phase bone scintigraphy as a complementary diagnostic method in chronic epicondylitis. Design A cross-sectional study. Setting Hospital outpatient clinic admitting patients with musculoskeletal disorders. Participants Patients (N=59; 68% women) with unilateral chronic epicondylitis. Interventions Not applicable. Main Outcome Measures Three-phase bone scintigraphy was performed after an intravenous injection of 550MBq99m technetium-labeled hydroxymethyline diphosphonate (99m Tc-HDP) in the patients. Blood flow and blood pool phases were graded visually as normative or abnormal. In the bone metabolic phase, the scintigraphic radiograph images were evaluated using a transmission densitometer. The ratio between maximal bone uptake of99m Tc-HDP in each epicondyle and the mean of that in the adjacent humerus was used as a bone uptake measure, which was compared with clinical data (pain questionnaire, pain drawing, cubital pain thresholds, muscle strength) and with work ability and lifestyle factors. Results The bone uptake of99m Tc-HDP of the affected epicondyle was 33% and 17% higher in men and women, respectively, compared with the corresponding healthy epicondyle ( P |
| doi_str_mv | 10.1016/j.apmr.2008.04.023 |
| format | Article |
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Three-phase bone scintigraphy in chronic epicondylitis. Objective To assess the utility of 3-phase bone scintigraphy as a complementary diagnostic method in chronic epicondylitis. Design A cross-sectional study. Setting Hospital outpatient clinic admitting patients with musculoskeletal disorders. Participants Patients (N=59; 68% women) with unilateral chronic epicondylitis. Interventions Not applicable. Main Outcome Measures Three-phase bone scintigraphy was performed after an intravenous injection of 550MBq99m technetium-labeled hydroxymethyline diphosphonate (99m Tc-HDP) in the patients. Blood flow and blood pool phases were graded visually as normative or abnormal. In the bone metabolic phase, the scintigraphic radiograph images were evaluated using a transmission densitometer. The ratio between maximal bone uptake of99m Tc-HDP in each epicondyle and the mean of that in the adjacent humerus was used as a bone uptake measure, which was compared with clinical data (pain questionnaire, pain drawing, cubital pain thresholds, muscle strength) and with work ability and lifestyle factors. Results The bone uptake of99m Tc-HDP of the affected epicondyle was 33% and 17% higher in men and women, respectively, compared with the corresponding healthy epicondyle ( P <.001 and P =.007). High bone uptake of99m Tc-HDP was associated with better work ability, grip strength, and muscle performance in both sexes but was not correlated with the pain measures. Blood flow phases had a positive correlation with the duration of symptoms and a negative correlation with the bone uptake of99m Tc-HDP, grip strength, and work ability. Conclusions High bone uptake of99m Tc-HDP among patients with chronic epicondylitis was associated with better muscle strength, work ability, and arm function. In chronic cases, a higher degree of bone uptake of99m Tc-HDP may thus indicate a healing response in the bone tissue.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1016/j.apmr.2008.04.023</identifier><identifier>PMID: 18996248</identifier><identifier>CODEN: APMHAI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Biomechanical Phenomena ; Bone and bones ; Chronic Disease ; Cross-Sectional Studies ; Diseases of the osteoarticular system ; Elbow Joint - diagnostic imaging ; Female ; Humans ; Humerus - diagnostic imaging ; Juxtaarticular diseases. Extraarticular rhumatism ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Pain Measurement ; Physical Medicine and Rehabilitation ; Radionuclide Imaging ; Radiopharmaceuticals ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rehabilitation ; Statistics, Nonparametric ; Technetium Tc 99m Medronate - analogs & derivatives ; Tennis Elbow - diagnostic imaging</subject><ispartof>Archives of physical medicine and rehabilitation, 2008-11, Vol.89 (11), p.2180-2184</ispartof><rights>American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2008 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-3e5c0559044ab3d9a9c7fd170c9d078d70621f222995175eed904f70d31455ee3</citedby><cites>FETCH-LOGICAL-c439t-3e5c0559044ab3d9a9c7fd170c9d078d70621f222995175eed904f70d31455ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apmr.2008.04.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20846342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18996248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pienimäki, Tuomo T., MD, PhD</creatorcontrib><creatorcontrib>Takalo, Reijo J., MD, PhD</creatorcontrib><creatorcontrib>Ahonen, Aapo K., MD, PhD</creatorcontrib><creatorcontrib>Karppinen, Jaro I., MD, PhD</creatorcontrib><title>Three-Phase Bone Scintigraphy in Chronic Epicondylitis</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>Abstract Pienimäki TT, Takalo RJ, Ahonen AK, Karppinen JI. Three-phase bone scintigraphy in chronic epicondylitis. Objective To assess the utility of 3-phase bone scintigraphy as a complementary diagnostic method in chronic epicondylitis. Design A cross-sectional study. Setting Hospital outpatient clinic admitting patients with musculoskeletal disorders. Participants Patients (N=59; 68% women) with unilateral chronic epicondylitis. Interventions Not applicable. Main Outcome Measures Three-phase bone scintigraphy was performed after an intravenous injection of 550MBq99m technetium-labeled hydroxymethyline diphosphonate (99m Tc-HDP) in the patients. Blood flow and blood pool phases were graded visually as normative or abnormal. In the bone metabolic phase, the scintigraphic radiograph images were evaluated using a transmission densitometer. The ratio between maximal bone uptake of99m Tc-HDP in each epicondyle and the mean of that in the adjacent humerus was used as a bone uptake measure, which was compared with clinical data (pain questionnaire, pain drawing, cubital pain thresholds, muscle strength) and with work ability and lifestyle factors. Results The bone uptake of99m Tc-HDP of the affected epicondyle was 33% and 17% higher in men and women, respectively, compared with the corresponding healthy epicondyle ( P <.001 and P =.007). High bone uptake of99m Tc-HDP was associated with better work ability, grip strength, and muscle performance in both sexes but was not correlated with the pain measures. Blood flow phases had a positive correlation with the duration of symptoms and a negative correlation with the bone uptake of99m Tc-HDP, grip strength, and work ability. Conclusions High bone uptake of99m Tc-HDP among patients with chronic epicondylitis was associated with better muscle strength, work ability, and arm function. In chronic cases, a higher degree of bone uptake of99m Tc-HDP may thus indicate a healing response in the bone tissue.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone and bones</subject><subject>Chronic Disease</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Elbow Joint - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Humerus - diagnostic imaging</subject><subject>Juxtaarticular diseases. Extraarticular rhumatism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Pain Measurement</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Rehabilitation</subject><subject>Statistics, Nonparametric</subject><subject>Technetium Tc 99m Medronate - analogs & derivatives</subject><subject>Tennis Elbow - diagnostic imaging</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVoabZJ_0AOxZfmZmf0YcuCUmiXtAkEGkgKvQlFGne18cqO5A3sv6_MLin0kNMw8LzD8LyEnFGoKNDmYl2ZcRMrBtBWICpg_IgsaM1Z2TL6-w1ZAAAvlVL8mLxPaZ3Xpub0HTmmrVINE-2CNPeriFjerkzC4tsQsLizPkz-TzTjalf4UCxXcQjeFpejt0Nwu95PPp2St53pE344zBPy6_vl_fKqvPn543r59aa0gqup5FhbqGsFQpgH7pRRVnaOSrDKgWydhIbRjjGmVE1ljegy2klwnIo6r_yEnO_vjnF42mKa9MYni31vAg7bpBslJWtkm0G2B20cUorY6TH6jYk7TUHPtvRaz7b0bEuD0NlWDn08XN8-bND9ixz0ZODTATDJmr6LJlifXjgGrWi4YJn7vOcwu3j2GHWyHoNF5yPaSbvBv_7Hl__itvfZuekfcYdpPWxjyJY11Ylp0Hdzr3Ot0AJIJSn_C-U_m2o</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Pienimäki, Tuomo T., MD, PhD</creator><creator>Takalo, Reijo J., MD, PhD</creator><creator>Ahonen, Aapo K., MD, PhD</creator><creator>Karppinen, Jaro I., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Three-Phase Bone Scintigraphy in Chronic Epicondylitis</title><author>Pienimäki, Tuomo T., MD, PhD ; Takalo, Reijo J., MD, PhD ; Ahonen, Aapo K., MD, PhD ; Karppinen, Jaro I., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-3e5c0559044ab3d9a9c7fd170c9d078d70621f222995175eed904f70d31455ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone and bones</topic><topic>Chronic Disease</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Elbow Joint - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Humerus - diagnostic imaging</topic><topic>Juxtaarticular diseases. Extraarticular rhumatism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Pain Measurement</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Rehabilitation</topic><topic>Statistics, Nonparametric</topic><topic>Technetium Tc 99m Medronate - analogs & derivatives</topic><topic>Tennis Elbow - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pienimäki, Tuomo T., MD, PhD</creatorcontrib><creatorcontrib>Takalo, Reijo J., MD, PhD</creatorcontrib><creatorcontrib>Ahonen, Aapo K., MD, PhD</creatorcontrib><creatorcontrib>Karppinen, Jaro I., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pienimäki, Tuomo T., MD, PhD</au><au>Takalo, Reijo J., MD, PhD</au><au>Ahonen, Aapo K., MD, PhD</au><au>Karppinen, Jaro I., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-Phase Bone Scintigraphy in Chronic Epicondylitis</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>89</volume><issue>11</issue><spage>2180</spage><epage>2184</epage><pages>2180-2184</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><coden>APMHAI</coden><abstract>Abstract Pienimäki TT, Takalo RJ, Ahonen AK, Karppinen JI. Three-phase bone scintigraphy in chronic epicondylitis. Objective To assess the utility of 3-phase bone scintigraphy as a complementary diagnostic method in chronic epicondylitis. Design A cross-sectional study. Setting Hospital outpatient clinic admitting patients with musculoskeletal disorders. Participants Patients (N=59; 68% women) with unilateral chronic epicondylitis. Interventions Not applicable. Main Outcome Measures Three-phase bone scintigraphy was performed after an intravenous injection of 550MBq99m technetium-labeled hydroxymethyline diphosphonate (99m Tc-HDP) in the patients. Blood flow and blood pool phases were graded visually as normative or abnormal. In the bone metabolic phase, the scintigraphic radiograph images were evaluated using a transmission densitometer. The ratio between maximal bone uptake of99m Tc-HDP in each epicondyle and the mean of that in the adjacent humerus was used as a bone uptake measure, which was compared with clinical data (pain questionnaire, pain drawing, cubital pain thresholds, muscle strength) and with work ability and lifestyle factors. Results The bone uptake of99m Tc-HDP of the affected epicondyle was 33% and 17% higher in men and women, respectively, compared with the corresponding healthy epicondyle ( P <.001 and P =.007). High bone uptake of99m Tc-HDP was associated with better work ability, grip strength, and muscle performance in both sexes but was not correlated with the pain measures. Blood flow phases had a positive correlation with the duration of symptoms and a negative correlation with the bone uptake of99m Tc-HDP, grip strength, and work ability. Conclusions High bone uptake of99m Tc-HDP among patients with chronic epicondylitis was associated with better muscle strength, work ability, and arm function. In chronic cases, a higher degree of bone uptake of99m Tc-HDP may thus indicate a healing response in the bone tissue.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18996248</pmid><doi>10.1016/j.apmr.2008.04.023</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biomechanical Phenomena Bone and bones Chronic Disease Cross-Sectional Studies Diseases of the osteoarticular system Elbow Joint - diagnostic imaging Female Humans Humerus - diagnostic imaging Juxtaarticular diseases. Extraarticular rhumatism Male Medical sciences Middle Aged Miscellaneous Pain Measurement Physical Medicine and Rehabilitation Radionuclide Imaging Radiopharmaceuticals Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rehabilitation Statistics, Nonparametric Technetium Tc 99m Medronate - analogs & derivatives Tennis Elbow - diagnostic imaging |
| title | Three-Phase Bone Scintigraphy in Chronic Epicondylitis |
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