CD36 LIMPII analogous-1, a human homolog of the rodent scavenger receptor B1, provides the cholesterol ester for steroidogenesis in adrenocortical cells
CD36 and LIMPII analogous-1 (CLA-1), a human homolog of the rodent scavenger receptor B1 (SR-B1), binds high-density lipoprotein (HDL) and mediates the selective uptake of HDL cholesterol ester (CE) by cultured transfected cells. CLA-1 is strongly expressed in steroidogenic tissues, including the ad...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1999-05, Vol.48 (5), p.627-630 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Imachi, Hitomi Murao, Koji Sato, Makoto Hosokawa, Hitoshi Ishida, Toshihiko Takahara, Jiro |
| description | CD36 and LIMPII analogous-1 (CLA-1), a human homolog of the rodent scavenger receptor B1 (SR-B1), binds high-density lipoprotein (HDL) and mediates the selective uptake of HDL cholesterol ester (CE) by cultured transfected cells. CLA-1 is strongly expressed in steroidogenic tissues, including the adrenal gland, suggesting that CLA-1 plays a role in providing substrates for steroidogenesis. To address this, we established an adrenocortical cell line that highly expresses CLA-1. These cells increased CE uptake from HDL to 140.5% of the level in mock-transfected cells. After incubation of the transfected cells with HDL, corticosterone secretion from CLA-1-transfected cells increased to about two times the level in mock-transfected cells. These results indicate the possibility that CLA-1 (a close structural homolog of SR-B1)-mediated uptake of HDL CE may be a significant source of precursor cholesterol for steroidogenesis in humans as it is in mice. |
| doi_str_mv | 10.1016/S0026-0495(99)90061-6 |
| format | Article |
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CLA-1 is strongly expressed in steroidogenic tissues, including the adrenal gland, suggesting that CLA-1 plays a role in providing substrates for steroidogenesis. To address this, we established an adrenocortical cell line that highly expresses CLA-1. These cells increased CE uptake from HDL to 140.5% of the level in mock-transfected cells. After incubation of the transfected cells with HDL, corticosterone secretion from CLA-1-transfected cells increased to about two times the level in mock-transfected cells. These results indicate the possibility that CLA-1 (a close structural homolog of SR-B1)-mediated uptake of HDL CE may be a significant source of precursor cholesterol for steroidogenesis in humans as it is in mice.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(99)90061-6</identifier><identifier>PMID: 10337864</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenal Cortex - metabolism ; Adrenal Cortex - pathology ; Animals ; Biological and medical sciences ; CD36 Antigens - metabolism ; Cell receptors ; Cell structures and functions ; Cholesterol Esters - metabolism ; Cholesterol Esters - pharmacokinetics ; Corticosterone - biosynthesis ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipoproteins, HDL - pharmacokinetics ; Mice ; Miscellaneous ; Molecular and cellular biology ; Receptors, Immunologic ; Receptors, Lipoprotein - metabolism ; Receptors, Scavenger ; Scavenger Receptors, Class B ; Transfection ; Tumor Cells, Cultured</subject><ispartof>Metabolism, clinical and experimental, 1999-05, Vol.48 (5), p.627-630</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-1b29280d86ddb11a918b08ca7dc832a7dd30b86f8c39c8ce3ad65b41d077cc4a3</citedby><cites>FETCH-LOGICAL-c508t-1b29280d86ddb11a918b08ca7dc832a7dd30b86f8c39c8ce3ad65b41d077cc4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049599900616$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1788758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10337864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imachi, Hitomi</creatorcontrib><creatorcontrib>Murao, Koji</creatorcontrib><creatorcontrib>Sato, Makoto</creatorcontrib><creatorcontrib>Hosokawa, Hitoshi</creatorcontrib><creatorcontrib>Ishida, Toshihiko</creatorcontrib><creatorcontrib>Takahara, Jiro</creatorcontrib><title>CD36 LIMPII analogous-1, a human homolog of the rodent scavenger receptor B1, provides the cholesterol ester for steroidogenesis in adrenocortical cells</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>CD36 and LIMPII analogous-1 (CLA-1), a human homolog of the rodent scavenger receptor B1 (SR-B1), binds high-density lipoprotein (HDL) and mediates the selective uptake of HDL cholesterol ester (CE) by cultured transfected cells. CLA-1 is strongly expressed in steroidogenic tissues, including the adrenal gland, suggesting that CLA-1 plays a role in providing substrates for steroidogenesis. To address this, we established an adrenocortical cell line that highly expresses CLA-1. These cells increased CE uptake from HDL to 140.5% of the level in mock-transfected cells. After incubation of the transfected cells with HDL, corticosterone secretion from CLA-1-transfected cells increased to about two times the level in mock-transfected cells. These results indicate the possibility that CLA-1 (a close structural homolog of SR-B1)-mediated uptake of HDL CE may be a significant source of precursor cholesterol for steroidogenesis in humans as it is in mice.</description><subject>Adrenal Cortex - metabolism</subject><subject>Adrenal Cortex - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CD36 Antigens - metabolism</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cholesterol Esters - metabolism</subject><subject>Cholesterol Esters - pharmacokinetics</subject><subject>Corticosterone - biosynthesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lipoproteins, HDL - pharmacokinetics</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Receptors, Immunologic</subject><subject>Receptors, Lipoprotein - metabolism</subject><subject>Receptors, Scavenger</subject><subject>Scavenger Receptors, Class B</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-LEzEUxYO4uHX1Iyh5EFHY0Zv5k0meRKu7FioK6nPIJHfayEzSTaYFv4kf13Ra1Def7uXyO8nhHEKeMHjFgPHXXwFKXkAtmxdSvpQAnBX8HlmwpioLwQHuk8Uf5JI8TOkHALSt4A_IJYOqylu9IL-W7ytO16tPX1Yrqr0ewibsU8Guqabb_ag93YYx5CsNPZ22SGOw6CeajD6g32CkEQ3uphDpuyzaxXBwFtOMmm0YME0Yw0DnSfuMzQdnwwY9Jpeo81TbiD6YECdn9EANDkN6RC56PSR8fJ5X5PvNh2_Lj8X68-1q-XZdmAbEVLCulKUAK7i1HWNaMtGBMLq1RlRlHraCTvBemEoaYbDSljddzWyOwphaV1fk-endbP1un22q0aWjA-0xJ6G4bFsGbZ3B5gSaGFKK2KtddKOOPxUDdaxEzZWoY95KSjVXonjWPT1_sO9GtP-oTh1k4NkZ0DnVoY_aG5f-cq0QbSMy9uaEYU7j4DCqZBx6g9blCiZlg_uPk987b6n-</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Imachi, Hitomi</creator><creator>Murao, Koji</creator><creator>Sato, Makoto</creator><creator>Hosokawa, Hitoshi</creator><creator>Ishida, Toshihiko</creator><creator>Takahara, Jiro</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>CD36 LIMPII analogous-1, a human homolog of the rodent scavenger receptor B1, provides the cholesterol ester for steroidogenesis in adrenocortical cells</title><author>Imachi, Hitomi ; Murao, Koji ; Sato, Makoto ; Hosokawa, Hitoshi ; Ishida, Toshihiko ; Takahara, Jiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-1b29280d86ddb11a918b08ca7dc832a7dd30b86f8c39c8ce3ad65b41d077cc4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenal Cortex - metabolism</topic><topic>Adrenal Cortex - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CD36 Antigens - metabolism</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cholesterol Esters - metabolism</topic><topic>Cholesterol Esters - pharmacokinetics</topic><topic>Corticosterone - biosynthesis</topic><topic>Fundamental and applied biological sciences. 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CLA-1 is strongly expressed in steroidogenic tissues, including the adrenal gland, suggesting that CLA-1 plays a role in providing substrates for steroidogenesis. To address this, we established an adrenocortical cell line that highly expresses CLA-1. These cells increased CE uptake from HDL to 140.5% of the level in mock-transfected cells. After incubation of the transfected cells with HDL, corticosterone secretion from CLA-1-transfected cells increased to about two times the level in mock-transfected cells. These results indicate the possibility that CLA-1 (a close structural homolog of SR-B1)-mediated uptake of HDL CE may be a significant source of precursor cholesterol for steroidogenesis in humans as it is in mice.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10337864</pmid><doi>10.1016/S0026-0495(99)90061-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Adrenal Cortex - metabolism Adrenal Cortex - pathology Animals Biological and medical sciences CD36 Antigens - metabolism Cell receptors Cell structures and functions Cholesterol Esters - metabolism Cholesterol Esters - pharmacokinetics Corticosterone - biosynthesis Fundamental and applied biological sciences. Psychology Humans Lipoproteins, HDL - pharmacokinetics Mice Miscellaneous Molecular and cellular biology Receptors, Immunologic Receptors, Lipoprotein - metabolism Receptors, Scavenger Scavenger Receptors, Class B Transfection Tumor Cells, Cultured |
| title | CD36 LIMPII analogous-1, a human homolog of the rodent scavenger receptor B1, provides the cholesterol ester for steroidogenesis in adrenocortical cells |
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