The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes
Fournier’s gangrene (FG) is a rare, rapidly progressive, fulminant form of necrotizing fasciitis of the genital, perianal and perineal regions. Several factors have been reported to contribute to the clinical outcomes. The primary aims of this study were to examine the clinical features of patients...
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| Veröffentlicht in: | International urology and nephrology 2008, Vol.40 (4), p.997-1004 |
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| creator | Kabay, Sahin Yucel, Mehmet Yaylak, Faik Algin, Mustafa C. Hacioglu, Alper Kabay, Burhan Muslumanoglu, Ahmet Y. |
| description | Fournier’s gangrene (FG) is a rare, rapidly progressive, fulminant form of necrotizing fasciitis of the genital, perianal and perineal regions. Several factors have been reported to contribute to the clinical outcomes. The primary aims of this study were to examine the clinical features of patients with FG and evaluate the predictivity of the Fournier’s Gangrene Severity Index (FGSI) score on the outcomes. We carried out a collective retrospective chart review of patients diagnosed and treated for FG in three reference centers between January 1995 and July 2007. Seventy-two patients with FG with were included to the study. Data were collected on medical history, symptoms, physical examination findings, admission and final laboratory tests, timing and extent of surgical debridement and antibiotic therapy. Perianal and perirectal abscess, scrotal abscess and urethral stenosis were the leading etiological factors. Diabetes mellitus was the predominant risk factor. Etiological factors and risk factors did not significantly contribute to survival or mortality, and duration of the symptoms was significantly longer in the non-survivor's group (
P
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| doi_str_mv | 10.1007/s11255-008-9401-4 |
| format | Article |
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P
< 0.05). The FGSI scores were higher in the non-survivor's group. Regression analysis showed a FGSIS score of 10.5 as the cut-off to the outcome. Based on these results, we conclude that a patient’s metabolic status and the extent of disease at presentation are the most important factors determining the prognosis of FG. The FGSI score may be considered as an objective and simple tool to predict the outcome in the patient with FG and should be used in further studies of FG patient series for comparison purposes.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-008-9401-4</identifier><identifier>PMID: 18563618</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Fournier Gangrene - diagnosis ; Fournier Gangrene - mortality ; Fournier Gangrene - physiopathology ; Fournier Gangrene - therapy ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Prognosis ; Regression Analysis ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Urology ; Urology-Original Paper</subject><ispartof>International urology and nephrology, 2008, Vol.40 (4), p.997-1004</ispartof><rights>Springer Science+Business Media, B.V. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-c12e468b9d8b6b903943e6bb996b0c5a9dcdb1cfcd4eacf57c762b7f578c2f13</citedby><cites>FETCH-LOGICAL-c435t-c12e468b9d8b6b903943e6bb996b0c5a9dcdb1cfcd4eacf57c762b7f578c2f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-008-9401-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-008-9401-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18563618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabay, Sahin</creatorcontrib><creatorcontrib>Yucel, Mehmet</creatorcontrib><creatorcontrib>Yaylak, Faik</creatorcontrib><creatorcontrib>Algin, Mustafa C.</creatorcontrib><creatorcontrib>Hacioglu, Alper</creatorcontrib><creatorcontrib>Kabay, Burhan</creatorcontrib><creatorcontrib>Muslumanoglu, Ahmet Y.</creatorcontrib><title>The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Fournier’s gangrene (FG) is a rare, rapidly progressive, fulminant form of necrotizing fasciitis of the genital, perianal and perineal regions. Several factors have been reported to contribute to the clinical outcomes. The primary aims of this study were to examine the clinical features of patients with FG and evaluate the predictivity of the Fournier’s Gangrene Severity Index (FGSI) score on the outcomes. We carried out a collective retrospective chart review of patients diagnosed and treated for FG in three reference centers between January 1995 and July 2007. Seventy-two patients with FG with were included to the study. Data were collected on medical history, symptoms, physical examination findings, admission and final laboratory tests, timing and extent of surgical debridement and antibiotic therapy. Perianal and perirectal abscess, scrotal abscess and urethral stenosis were the leading etiological factors. Diabetes mellitus was the predominant risk factor. Etiological factors and risk factors did not significantly contribute to survival or mortality, and duration of the symptoms was significantly longer in the non-survivor's group (
P
< 0.05). The FGSI scores were higher in the non-survivor's group. Regression analysis showed a FGSIS score of 10.5 as the cut-off to the outcome. Based on these results, we conclude that a patient’s metabolic status and the extent of disease at presentation are the most important factors determining the prognosis of FG. The FGSI score may be considered as an objective and simple tool to predict the outcome in the patient with FG and should be used in further studies of FG patient series for comparison purposes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Fournier Gangrene - diagnosis</subject><subject>Fournier Gangrene - mortality</subject><subject>Fournier Gangrene - physiopathology</subject><subject>Fournier Gangrene - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><subject>Urology</subject><subject>Urology-Original Paper</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1O5DAQhS00CJqfA7AZRbNgFyg7thMvEeJPQmJB7y3bqTRBaafHTtCwgmtwvTnJOHQjxEisbJW_98pVj5AjCicUoDyNlDIhcoAqVxxozrfIjIqyyJmo-A8ygyIVqWTFLtmL8REAVAWwQ3ZpJWQhaTUjL_MHzFzX-taZLmvQDGPAmPVNdtmPwbcY_r6-xWxh_CKgx8z4OhuSZBWwbt3QPrXD80RPtS-Kqw_FPT5hmKgbX-OfrPfvbD8Orl9iPCDbjekiHm7OfTK_vJifX-e3d1c352e3ueOFGHJHGXJZWVVXVloFheIFSmuVkhacMKp2taWucTVH4xpRulIyW6ZL5VhDi31yvLZdhf73iHHQyzY67DrjsR-jlqqUCkAk8Nd_4OM0VfqaZjRtTDEOCaJryIU-xoCNXoV2acKzpqCnZPQ6GZ2S0VMymifNz43xaJdYfyo2USSArYGYnvwCw2fn713_AcVFnQM</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Kabay, Sahin</creator><creator>Yucel, Mehmet</creator><creator>Yaylak, Faik</creator><creator>Algin, Mustafa C.</creator><creator>Hacioglu, Alper</creator><creator>Kabay, Burhan</creator><creator>Muslumanoglu, Ahmet Y.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes</title><author>Kabay, Sahin ; Yucel, Mehmet ; Yaylak, Faik ; Algin, Mustafa C. ; Hacioglu, Alper ; Kabay, Burhan ; Muslumanoglu, Ahmet Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-c12e468b9d8b6b903943e6bb996b0c5a9dcdb1cfcd4eacf57c762b7f578c2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Fournier Gangrene - diagnosis</topic><topic>Fournier Gangrene - mortality</topic><topic>Fournier Gangrene - physiopathology</topic><topic>Fournier Gangrene - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><topic>Urology</topic><topic>Urology-Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabay, Sahin</creatorcontrib><creatorcontrib>Yucel, Mehmet</creatorcontrib><creatorcontrib>Yaylak, Faik</creatorcontrib><creatorcontrib>Algin, Mustafa C.</creatorcontrib><creatorcontrib>Hacioglu, Alper</creatorcontrib><creatorcontrib>Kabay, Burhan</creatorcontrib><creatorcontrib>Muslumanoglu, Ahmet Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabay, Sahin</au><au>Yucel, Mehmet</au><au>Yaylak, Faik</au><au>Algin, Mustafa C.</au><au>Hacioglu, Alper</au><au>Kabay, Burhan</au><au>Muslumanoglu, Ahmet Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2008</date><risdate>2008</risdate><volume>40</volume><issue>4</issue><spage>997</spage><epage>1004</epage><pages>997-1004</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Fournier’s gangrene (FG) is a rare, rapidly progressive, fulminant form of necrotizing fasciitis of the genital, perianal and perineal regions. Several factors have been reported to contribute to the clinical outcomes. The primary aims of this study were to examine the clinical features of patients with FG and evaluate the predictivity of the Fournier’s Gangrene Severity Index (FGSI) score on the outcomes. We carried out a collective retrospective chart review of patients diagnosed and treated for FG in three reference centers between January 1995 and July 2007. Seventy-two patients with FG with were included to the study. Data were collected on medical history, symptoms, physical examination findings, admission and final laboratory tests, timing and extent of surgical debridement and antibiotic therapy. Perianal and perirectal abscess, scrotal abscess and urethral stenosis were the leading etiological factors. Diabetes mellitus was the predominant risk factor. Etiological factors and risk factors did not significantly contribute to survival or mortality, and duration of the symptoms was significantly longer in the non-survivor's group (
P
< 0.05). The FGSI scores were higher in the non-survivor's group. Regression analysis showed a FGSIS score of 10.5 as the cut-off to the outcome. Based on these results, we conclude that a patient’s metabolic status and the extent of disease at presentation are the most important factors determining the prognosis of FG. The FGSI score may be considered as an objective and simple tool to predict the outcome in the patient with FG and should be used in further studies of FG patient series for comparison purposes.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>18563618</pmid><doi>10.1007/s11255-008-9401-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International urology and nephrology, 2008, Vol.40 (4), p.997-1004 |
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| subjects | Adult Aged Aged, 80 and over Female Fournier Gangrene - diagnosis Fournier Gangrene - mortality Fournier Gangrene - physiopathology Fournier Gangrene - therapy Humans Male Medicine Medicine & Public Health Middle Aged Nephrology Prognosis Regression Analysis Retrospective Studies Severity of Illness Index Treatment Outcome Urology Urology-Original Paper |
| title | The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes |
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