Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection
Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured...
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| Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 1999-05, Vol.11 (2), p.222-233 |
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| container_title | The journal of neuropsychiatry and clinical neurosciences |
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| creator | Wiseman, Mary Beth Sanchez, Jorge A Buechel, Christian Mintun, Mark A Lopez, Oscar L Milko, Donna Becker, James T |
| description | Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured with PET imaging in HIV+ MCMD patients, HIV+ control subjects, and HIV- control subjects; analyses were performed by using statistical parametric mapping. Comparing a short-term memory task versus a rest state yielded activation in superior temporal cortex, postcentral gyrus, and cerebellum in all three subject groups. Comparing long- and short-term memory tasks yielded activation throughout the frontal cortex, including BA46. Activation in this area was reduced in the HIV+ control subjects and further reduced in the MCMD+ patients. Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal. |
| doi_str_mv | 10.1176/jnp.11.2.222 |
| format | Article |
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Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured with PET imaging in HIV+ MCMD patients, HIV+ control subjects, and HIV- control subjects; analyses were performed by using statistical parametric mapping. Comparing a short-term memory task versus a rest state yielded activation in superior temporal cortex, postcentral gyrus, and cerebellum in all three subject groups. Comparing long- and short-term memory tasks yielded activation throughout the frontal cortex, including BA46. Activation in this area was reduced in the HIV+ control subjects and further reduced in the MCMD+ patients. Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal.</description><subject>AIDS/HIV</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cognition Disorders - diagnostic imaging</subject><subject>Cognition Disorders - physiopathology</subject><subject>HIV Infections - diagnostic imaging</subject><subject>HIV Infections - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Task Performance and Analysis</subject><subject>Tomography, Emission-Computed</subject><issn>0895-0172</issn><issn>1545-7222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1r3DAQxUVJaDbb3noOIodCoN7ow7KsY7v5WkhIKW2vQrbGQYstOZLdkP8-SjeHEHKaN8OPN8MbhL5QsqJUVqdbP2axYivG2Ae0oKIUhcx6Dy1IrURBqGQH6DClLSGE8ar8iA4o4ZwrxRdo-mmmCaJPOHT4F_Rmcv8AryFCE02Pf_QhWHzRhwfsPL5xPkS8Dnfe_cduwpT7M5dCtBCfiat5MB5vhmH2wULnWge-fcR_XZwT3vgO2skF_wntd6ZP8PmlLtGfi_Pf66vi-vZys_5-XRhOxFRAWQNRVtaEsaYktuJlXauOSW6tyBNDiW2UbUglQUkCnTJSdty0VctKa4Av0ded7xjD_Qxp0oNLLfS98RDmpCslq1qIKoPHb8BtmKPPt2mqBBOszokt0bcd1MaQUoROj9ENJj5qSvTzK3R-RRaa6Rx_xo9ePOdmAPsK3mWfgZMdYMbRvVr4ntkTTICSiw</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>Wiseman, Mary Beth</creator><creator>Sanchez, Jorge A</creator><creator>Buechel, Christian</creator><creator>Mintun, Mark A</creator><creator>Lopez, Oscar L</creator><creator>Milko, Donna</creator><creator>Becker, James T</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Publishing, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection</title><author>Wiseman, Mary Beth ; Sanchez, Jorge A ; Buechel, Christian ; Mintun, Mark A ; Lopez, Oscar L ; Milko, Donna ; Becker, James T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a305t-e48e09d78022b40d634889f273dd52b4a10db9db067e970ef9a77f3ac6c24dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AIDS/HIV</topic><topic>Brain - diagnostic imaging</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cognition Disorders - diagnostic imaging</topic><topic>Cognition Disorders - physiopathology</topic><topic>HIV Infections - diagnostic imaging</topic><topic>HIV Infections - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Task Performance and Analysis</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiseman, Mary Beth</creatorcontrib><creatorcontrib>Sanchez, Jorge A</creatorcontrib><creatorcontrib>Buechel, Christian</creatorcontrib><creatorcontrib>Mintun, Mark A</creatorcontrib><creatorcontrib>Lopez, Oscar L</creatorcontrib><creatorcontrib>Milko, Donna</creatorcontrib><creatorcontrib>Becker, James T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiseman, Mary Beth</au><au>Sanchez, Jorge A</au><au>Buechel, Christian</au><au>Mintun, Mark A</au><au>Lopez, Oscar L</au><au>Milko, Donna</au><au>Becker, James T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection</atitle><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><date>1999-05</date><risdate>1999</risdate><volume>11</volume><issue>2</issue><spage>222</spage><epage>233</epage><pages>222-233</pages><issn>0895-0172</issn><eissn>1545-7222</eissn><coden>JNCNE7</coden><abstract>Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. 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Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>10333993</pmid><doi>10.1176/jnp.11.2.222</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Psychiatry Legacy Collection Online Journals 1844-1996 |
| subjects | AIDS/HIV Brain - diagnostic imaging Cerebrovascular Circulation - physiology Cognition Disorders - diagnostic imaging Cognition Disorders - physiopathology HIV Infections - diagnostic imaging HIV Infections - physiopathology Humans Male Memory - physiology Task Performance and Analysis Tomography, Emission-Computed |
| title | Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection |
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