Synthesis and Antiviral Activity of 1-[(1,5-Dialkyl-1H-1,2,4-triazol-3-yl)methyl]thymines

Cycloaddition of the intermediates 2 with 1‐(cyanomethyl)‐thymine 3 furnished the 1,2,4‐triazolium salts 4, which rearranged spontaneously to the protonated salts 5. Hydrolysis of 5, in situ, afforded the title compounds 6. Compounds 6a‐c were screened against HIV‐1 (IIIB), HIV‐2 (ROD), and human cy...

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