Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy

Combined antiplatelet therapy reduces recurrent atherothrombotic events in stable coronary disease patients; however, high residual platelet reactivity measured ex vivo still raises concerns as a condition related to treatment failure. Alpha-2 adrenoceptor enhances platelet reactivity and might cont...

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Veröffentlicht in:	Thrombosis and haemostasis 2008-11, Vol.100 (5), p.829-838
Hauptverfasser:	Béres, Bernát János, Tóth-Zsámboki, Emese, Vargová, Katarína, László, Adám, Masszi, Tamás, Kerecsen, Gábor, Préda, István, Kiss, Róbert Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Adrenergic alpha-Antagonists - pharmacology Aged Aspirin Blood Platelets - drug effects Blood Platelets - metabolism Collagen Coronary Artery Disease - blood Coronary Artery Disease - drug therapy Drug Resistance Drug Therapy, Combination Female Humans Imidazoles - pharmacology Male Middle Aged Norepinephrine - blood Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - therapeutic use Platelet Function Tests Receptors, Adrenergic, alpha-2 - blood Receptors, Adrenergic, alpha-2 - drug effects Receptors, Purinergic P2 - blood Receptors, Purinergic P2 - drug effects Receptors, Purinergic P2Y12 Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use Treatment Failure
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