A Genetic Polymorphism in the Promoter Region of DRD4 Associated with Expression and Schizophrenia

The human dopamine D4 receptor gene (DRD4) is an important candidate gene for schizophrenia. We identified a novel −521C>T polymorphism in the 5′-promoter region of DRD4. A transient expression method revealed that the T allele of this polymorphism reduces the transcriptional efficiency by 40% co...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-05, Vol.258 (2), p.292-295
Hauptverfasser:	Okuyama, Yuki, Ishiguro, Hiroki, Toru, Michio, Arinami, Tadao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence Chloramphenicol O-Acetyltransferase - genetics DNA Primers dopamine D4 receptors drd4 gene Female Genotype Humans Male Middle Aged Polymorphism, Genetic Promoter Regions, Genetic Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 RNA, Messenger - genetics Schizophrenia - genetics
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