Prevalence of mutations in APC , CTNNB1 , and BRAF in Tunisian patients with sporadic colorectal cancer

Abstract Sporadic colorectal tumorigenesis is caused by alterations in the Wnt ( APC , CTNNB1 ) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics. The prevalence of somatic alteration in the hot-spot regions of...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2008-11, Vol.187 (1), p.12-18
Hauptverfasser:	Bougatef, Karim, Ouerhani, Slah, Moussa, Amel, Kourda, Nadia, Coulet, Florence, Colas, Chrystelle, Lahely, Yannick Blondeau, Najjar, Tawfik, Ben Jilani, Sarra, Benammar-Elgaaied, Amel, Soubrier, Florent, Marrakchi, Raja
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged beta Catenin - genetics Colorectal Neoplasms - genetics DNA Mutational Analysis DNA Primers DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Exons Female Gene Amplification Genes, APC Hematology, Oncology and Palliative Medicine Humans Loss of Heterozygosity Male Medical Education Middle Aged Mutation Point Mutation Polymerase Chain Reaction Proto-Oncogene Proteins B-raf - genetics Tunisia
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