On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses
Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive...
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| Veröffentlicht in: | Seminars in immunology 1999-04, Vol.11 (2), p.95-104 |
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| container_title | Seminars in immunology |
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| creator | DeVries, Mark E. Ran, L. Kelvin, David J. |
| description | Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice. |
| doi_str_mv | 10.1006/smim.1999.0165 |
| format | Article |
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We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Chemokines - physiology</subject><subject>chemokines, in vivo, transplantation, rheumatoid arthritis, transgenic</subject><subject>Graft Rejection - immunology</subject><subject>Humans</subject><subject>Mice</subject><issn>1044-5323</issn><issn>1096-3618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi1U1OWj1x6rnHrLYseOHfeGEAWklbjA2XLsya5pbKd2gth_34RFantAnGY0et73MA9CXwleE4z5RfbOr4mUco0Jr4_QCcGSl5ST5tOyM1bWtKIrdJrzE8aYsoZ8RiuCaSWZ5Cfo5T4U4w4KsFv48boNu312sY9bZ3Rf6GCLQY-7-P85xR6K2BVmBz7-cgFyYafkwrZwoeu193qMaf-adt5P4W8Q8hBDhnyOjjvdZ_jyNs_Q48_rh6vbcnN_c3d1uSkNo2IsSVvx1taGiVY0WsgGaFMR07R110grjWhZXVPaMahZJaWmXLP5L7qTLe-o1fQMfT_0Din-niCPyrtsoO91gDhlxaXghAn2IUhExRirxQyuD6BJMecEnRqS8zrtFcFqkaIWKWqRohYpc-DbW_PUerD_4AcLM9AcAJgf8ewgqWwcBAPWJTCjstG91_0Hd0ueNA</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>DeVries, Mark E.</creator><creator>Ran, L.</creator><creator>Kelvin, David J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses</title><author>DeVries, Mark E. ; Ran, L. ; Kelvin, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-1b26bd5c47b78a798e3821c8b5f89d9c7b45533f4e54299a36a4006af9b6f3da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Chemokines - physiology</topic><topic>chemokines, in vivo, transplantation, rheumatoid arthritis, transgenic</topic><topic>Graft Rejection - immunology</topic><topic>Humans</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeVries, Mark E.</creatorcontrib><creatorcontrib>Ran, L.</creatorcontrib><creatorcontrib>Kelvin, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeVries, Mark E.</au><au>Ran, L.</au><au>Kelvin, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses</atitle><jtitle>Seminars in immunology</jtitle><addtitle>Semin Immunol</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>11</volume><issue>2</issue><spage>95</spage><epage>104</epage><pages>95-104</pages><issn>1044-5323</issn><eissn>1096-3618</eissn><abstract>Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. 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| ispartof | Seminars in immunology, 1999-04, Vol.11 (2), p.95-104 |
| issn | 1044-5323 1096-3618 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arthritis, Rheumatoid - immunology Chemokines - physiology chemokines, in vivo, transplantation, rheumatoid arthritis, transgenic Graft Rejection - immunology Humans Mice |
| title | On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses |
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