p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor

The Brn-3a POU family transcription factor has been shown to strongly activate expression of the Bcl-2proto-oncogene and thereby protect neuronal cells from programmed cell death (apoptosis). This activation of the Bcl-2 promoter by Brn-3a is strongly inhibited by the p53 anti-oncogene protein. This...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 1999-05, Vol.274 (21), p.15237-15244
Hauptverfasser:	Budhram-Mahadeo, Vishwanie, Morris, Peter J., Smith, Martin D., Midgley, Carol A., Boxer, Linda M., Latchman, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured DNA-Binding Proteins - physiology Genes, bcl-2 - genetics Genes, bcl-2 - physiology Genes, p53 - physiology Promoter Regions, Genetic Transcription Factor Brn-3 Transcription Factors - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!