Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

Glutamic acid decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic (NOD) mice. β Cell-specific suppression of GAD expression in two lines of antisense GAD transgenic NOD mice prevented autoimmune diabetes, whereas persistent GAD expression in the β cells in the othe...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5417), p.1183-1187
Hauptverfasser:	Yoon, Ji-Won, Yoon, Chang-Soon, Lim, Hye-Won, Huang, Qi Quan, Kang, Yup, Pyun, Kwang Ho, Hirasawa, Kensuke, Sherwin, Robert S., Jun, Hee-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Autoantigens - genetics Autoantigens - immunology Autoantigens - physiology Autoimmune diseases Autoimmunity Biological and medical sciences Cell lines Diabetes Diabetes complications Diabetes Mellitus, Type 1 - enzymology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes. Impaired glucose tolerance DNA, Antisense Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Expression Glutamate decarboxylase Glutamate Decarboxylase - genetics Glutamate Decarboxylase - immunology Glutamate Decarboxylase - physiology Insulin Insulin - blood Insulin - metabolism Islets of Langerhans - enzymology Islets of Langerhans - immunology Islets of Langerhans - metabolism Islets of Langerhans - pathology Islets of Langerhans Transplantation Lymphocyte Activation Male Medical sciences Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Physiological aspects Prevention Splenocytes T lymphocytes T-Lymphocytes - immunology Transgenes Transgenic animals Type 1 diabetes Type 1 diabetes mellitus
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