Galardin Inhibits Collagen Degradation by Rabbit Keratocytes by Inhibiting the Activation of Pro-Matrix Metalloproteinases

We investigated the inhibitory action of a synthetic peptidyl hydroxamate inhibitor of matrix metalloproteinase (MMP), Galardin (GM6001), on collagen degradation by rabbit corneal stromal fibroblasts (keratocytes) cultured three-dimensionally in the type I collagen gel with medium containing interle...

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Veröffentlicht in:	Experimental eye research 1999-05, Vol.68 (5), p.565-572
Hauptverfasser:	HAO, JI-LONG, NAGANO, TAKASHI, NAKAMURA, MASATSUGU, KUMAGAI, NAOKI, MISHIMA, HIROSHI, NISHIDA, TERUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cells, Cultured Collagen - metabolism collagen degradation Cornea - drug effects Cornea - metabolism Dipeptides - pharmacology Electrophoresis, Polyacrylamide Gel Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Enzyme Precursors - antagonists & inhibitors Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Galardin Hydroxyproline - analysis interleukin 1α Interleukin-1 - metabolism keratocyte Male matrix metalloproteinase Metalloendopeptidases - antagonists & inhibitors Plasminogen - metabolism Rabbits Vertebrates: nervous system and sense organs
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