Tonic activity of Galpha-gustducin regulates taste cell responsivity

The taste-selective G protein, alpha-gustducin (alpha-gus) is homologous to alpha-transducin and activates phosphodiesterase (PDE) in vitro. alpha-Gus-knockout mice are compromized to bitter, sweet and umami taste stimuli, suggesting a central role in taste transduction. Here, we suggest a different...

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Veröffentlicht in:	FEBS letters 2008-11, Vol.582 (27), p.3783-3787
Hauptverfasser:	Clapp, Tod R, Trubey, Kristina R, Vandenbeuch, Aurelie, Stone, Leslie M, Margolskee, Robert F, Chaudhari, Nirupa, Kinnamon, Sue C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Signaling Cyclic AMP - metabolism Heterotrimeric GTP-Binding Proteins - genetics Heterotrimeric GTP-Binding Proteins - metabolism Isoquinolines - pharmacology Mice Mice, Knockout Protein Kinase Inhibitors - pharmacology Quaternary Ammonium Compounds - pharmacology Sulfonamides - pharmacology Taste Taste Buds - drug effects Taste Buds - enzymology Taste Buds - physiology
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