Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro
Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propo...
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Veröffentlicht in: | British journal of anaesthesia : BJA 1999-01, Vol.82 (1), p.38-40 |
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description | Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin. |
doi_str_mv | 10.1093/bja/82.1.38 |
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We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/82.1.38</identifier><identifier>PMID: 10325833</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adhesiveness ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. 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We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin.</description><subject>Adhesiveness</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesia: equipment, devices</subject><subject>Anesthetics, Intravenous - chemistry</subject><subject>Anticoagulants</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary Bypass - instrumentation</subject><subject>Coated Materials, Biocompatible</subject><subject>Extracorporeal Circulation - instrumentation</subject><subject>Heparin</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Propofol - chemistry</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1r3DAQxUVJSbZpT70XEUIvxRuNZVnyMSz9CAR6ac9ClseNFq_kSvK2-e-rdBcSSqCngeE3b957hLwFtgbW8at-a65UvYY1Vy_IChoJVSslnJAVY0xWrIP6jLxKacsYyLoTp-QMGK-F4nxF-k0w2fkfNIwUf-dobIhziGgmal20i8v0l8t39A5nE52nQ8BEfch0jrhHn2nCnwumcphd8A8qcwxzGMNEC713OYbX5OVopoRvjvOcfP_08dvmS3X79fPN5vq2so0QuWpBYj90bSfHth5E04Dkg5FGKQUt71VZjqKvWxAge2lba1CZQamSZDSGM35O3h90i4O_nvTOJYvTZDyGJemiLJquawp48Q-4DUv0xZuGTkolyosCfThANoaUIo56jm5n4r0Gph9616V3rWoNmqtCvztKLv0OhyfsoegCXB4Bk6yZxmi8demRayU0TzOEZf7PQ3EAsTS6dxh1sg69xcFFtFkPwT179wcrdqoa</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Hammarén, E</creator><creator>Rosenberg, P H</creator><creator>Hynynen, M</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro</title><author>Hammarén, E ; Rosenberg, P H ; Hynynen, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-617ebd9697f62d544173da7a888163b862df5b261517b7c6cae8ad88325faa303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adhesiveness</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesia: equipment, devices</topic><topic>Anesthetics, Intravenous - chemistry</topic><topic>Anticoagulants</topic><topic>Biological and medical sciences</topic><topic>Cardiopulmonary Bypass - instrumentation</topic><topic>Coated Materials, Biocompatible</topic><topic>Extracorporeal Circulation - instrumentation</topic><topic>Heparin</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Propofol - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammarén, E</creatorcontrib><creatorcontrib>Rosenberg, P H</creatorcontrib><creatorcontrib>Hynynen, M</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammarén, E</au><au>Rosenberg, P H</au><au>Hynynen, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>1999-01</date><risdate>1999</risdate><volume>82</volume><issue>1</issue><spage>38</spage><epage>40</epage><pages>38-40</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10325833</pmid><doi>10.1093/bja/82.1.38</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adhesiveness Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesia: equipment, devices Anesthetics, Intravenous - chemistry Anticoagulants Biological and medical sciences Cardiopulmonary Bypass - instrumentation Coated Materials, Biocompatible Extracorporeal Circulation - instrumentation Heparin Humans Medical sciences Propofol - chemistry |
title | Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro |
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