Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro

Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propo...

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Veröffentlicht in:British journal of anaesthesia : BJA 1999-01, Vol.82 (1), p.38-40
Hauptverfasser: Hammarén, E, Rosenberg, P H, Hynynen, M
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Rosenberg, P H
Hynynen, M
description Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adhesiveness
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesia: equipment, devices
Anesthetics, Intravenous - chemistry
Anticoagulants
Biological and medical sciences
Cardiopulmonary Bypass - instrumentation
Coated Materials, Biocompatible
Extracorporeal Circulation - instrumentation
Heparin
Humans
Medical sciences
Propofol - chemistry
title Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro
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