Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA

Previously, we have shown that 7-week oral nicotine treatment enhances morphine-induced behaviors and dopaminergic activity in the mouse brain. In this study, we further characterized the nicotine-morphine interaction in the mesolimbic and nigrostriatal dopaminergic systems, as well as in the GABAer...

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Veröffentlicht in:	Journal of neurochemistry 2008-11, Vol.107 (3), p.844-854
Hauptverfasser:	Vihavainen, Tanja, Relander, Toni R.A, Leiviskä, Riikka, Airavaara, Mikko, Tuominen, Raimo K, Ahtee, Liisa, Piepponen, Timo Petteri
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-dyhydroxylphenylalanine 3-hydroxybenzylhydrazine dihydrochloride Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biochemistry Biological and medical sciences Brain - drug effects Brain - metabolism caudate putamen Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors chronic oral nicotine treatment Dihydroxyphenylalanine - metabolism dopamine Dopamine - metabolism Extracellular Fluid - metabolism Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - drug effects gamma-Aminobutyric Acid - metabolism Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Male Medical sciences Mice Microdialysis morphine Morphine - pharmacology Motor Activity - drug effects Narcotics Narcotics - pharmacology Neurology Neuropharmacology Neurotransmitter Agents - metabolism Neurotransmitters Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology nipecotic acid nucleus accumbens Pharmacology. Drug treatments Rodents substantia nigra Time ventral tegmental area Vertebrates: nervous system and sense organs α-methyltyrosine
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